Salgar, SK and Shapiro, R and Dodson, F and Corry, R and McCurry, K and Zeevi, A and Pham, S and Abu-Elmagd, K and Reyes, J and Jordan, M and Keenan, R and Griffith, B and Sesky, T and Ostrowski, L and Starzl, TE and Fung, JJ and Rao, AS
(1999)
Infusion of donor leukocytes to induce tolerance in organ allograft recipients.
Journal of Leukocyte Biology, 66 (2).
310 - 314.
ISSN 0741-5400
Abstract
To further enhance chimerism, 229 primary allograft recipients have received perioperative intravenous infusion of a single dose of 3 to 6 x 108 unmodified donor bone marrow (BM) cells/kg body weight. In addition, 42 patients have been accrued in a concurrent protocol involving multiple (up to three) sequential perioperative infusions of 2 x 108 BM cells/kg/day from day 0-2 posttransplantation (PTx). Organ recipients (n = 133) for whom BM was not available were monitored as controls. The infusion of BM was safe and except for 50 (18%), all study patients have optimal graft function. Of the control patients, allografts in 30 (23%) have been lost during the course of follow-up. The cumulative risk of acute cellular rejection (ACR) was statistically lower in the study patients compared with that of controls. It is interesting that, 62% of BM-augmented heart recipients were free of ACR (Grade ≥ 3A) in the first 6 months PTx compared to controls. The incidence of obliterative bronchiolitis was also statistically lower in study lung recipients (3.8%) compared with the contemporaneously acquired controls (31%). The levels of donor cell chimerism were at least a log higher in the peripheral blood of majority of the study patients compared with that of controls. The incidence of donor-specific hyporeactivity, as determined by one-way mixed leukocyte reaction, was also higher in those BM-augmented liver, kidney, and lung recipients that could be evaluated compared to controls.
Share
Citation/Export: |
|
Social Networking: |
|
Details
Item Type: |
Article
|
Status: |
Published |
Creators/Authors: |
Creators | Email | Pitt Username | ORCID |
---|
Salgar, SK | | | | Shapiro, R | | | | Dodson, F | | | | Corry, R | | | | McCurry, K | | | | Zeevi, A | | | | Pham, S | | | | Abu-Elmagd, K | | | | Reyes, J | | | | Jordan, M | | | | Keenan, R | | | | Griffith, B | | | | Sesky, T | | | | Ostrowski, L | | | | Starzl, TE | tes11@pitt.edu | TES11 | | Fung, JJ | | | | Rao, AS | | | |
|
Centers: |
Other Centers, Institutes, Offices, or Units > Thomas E. Starzl Transplantation Institute |
Date: |
1 January 1999 |
Date Type: |
Publication |
Journal or Publication Title: |
Journal of Leukocyte Biology |
Volume: |
66 |
Number: |
2 |
Page Range: |
310 - 314 |
DOI or Unique Handle: |
10.1002/jlb.66.2.310 |
Institution: |
University of Pittsburgh |
Refereed: |
Yes |
ISSN: |
0741-5400 |
Other ID: |
uls-drl:31735062127786, Starzl CV No. 2057 |
Date Deposited: |
08 Apr 2010 17:35 |
Last Modified: |
22 Jun 2021 14:56 |
URI: |
http://d-scholarship.pitt.edu/id/eprint/5443 |
Metrics
Monthly Views for the past 3 years
Plum Analytics
Altmetric.com
Actions (login required)
|
View Item |