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Infusion of donor leukocytes to induce tolerance in organ allograft recipients

Salgar, SK and Shapiro, R and Dodson, F and Corry, R and McCurry, K and Zeevi, A and Pham, S and Abu-Elmagd, K and Reyes, J and Jordan, M and Keenan, R and Griffith, B and Sesky, T and Ostrowski, L and Starzl, TE and Fung, JJ and Rao, AS (1999) Infusion of donor leukocytes to induce tolerance in organ allograft recipients. Journal of Leukocyte Biology, 66 (2). 310 - 314. ISSN 0741-5400

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Abstract

To further enhance chimerism, 229 primary allograft recipients have received perioperative intravenous infusion of a single dose of 3 to 6 x 10 8 unmodified donor bone marrow (BM) cells/kg body weight. In addition, 42 patients have been accrued in a concurrent protocol involving multiple (up to three) sequential perioperative infusions of 2 x 10 8 BM cells/kg/day from day 0-2 posttransplantation (PTx). Organ recipients (n = 133) for whom BM was not available were monitored as controls. The infusion of BM was safe and except for 50 (18%), all study patients have optimal graft function. Of the control patients, allografts in 30 (23%) have been lost during the course of follow-up. The cumulative risk of acute cellular rejection (ACR) was statistically lower in the study patients compared with that of controls. It is interesting that, 62% of BM-augmented heart recipients were free of ACR (Grade ≥ 3A) in the first 6 months PTx compared to controls. The incidence of obliterative bronchiolitis was also statistically lower in study lung recipients (3.8%) compared with the contemporaneously acquired controls (31%). The levels of donor cell chimerism were at least a log higher in the peripheral blood of majority of the study patients compared with that of controls. The incidence of donor-specific hyporeactivity, as determined by one-way mixed leukocyte reaction, was also higher in those BM-augmented liver, kidney, and lung recipients that could be evaluated compared to controls.


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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Salgar, SK
Shapiro, R
Dodson, F
Corry, R
McCurry, K
Zeevi, A
Pham, S
Abu-Elmagd, K
Reyes, J
Jordan, M
Keenan, R
Griffith, B
Sesky, T
Ostrowski, L
Starzl, TEtes11@pitt.eduTES11
Fung, JJ
Rao, AS
Centers: Other Centers, Institutes, or Units > Thomas E. Starzl Transplantation Institute
Date: 20 August 1999
Date Type: Publication
Journal or Publication Title: Journal of Leukocyte Biology
Volume: 66
Number: 2
Page Range: 310 - 314
Institution: University of Pittsburgh
Refereed: Yes
ISSN: 0741-5400
Other ID: uls-drl:31735062127786, Starzl CV No. 2057
Date Deposited: 08 Apr 2010 17:35
Last Modified: 13 Oct 2017 17:55
URI: http://d-scholarship.pitt.edu/id/eprint/5443

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