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Effects of donor bone marrow infusion in clinical lung transplantation

Pham, SM and Rao, AS and Zeevi, A and McCurry, KR and Keenan, RJ and Vega, JD and Kormos, RL and Hattler, BG and Fung, JJ and Starzl, TE and Griffith, BP (2000) Effects of donor bone marrow infusion in clinical lung transplantation. Annals of Thoracic Surgery, 69 (2). 345 - 350. ISSN 0003-4975

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Abstract

Background. We have demonstrated that donor cell chimerism is associated with a lower incidence of obliterative bronchiolitis (OB) in lung recipients, and that donor chimerism is augmented by the infusion of donor bone marrow (BM). We herein report the intermediate results of a trial combining the infusion of donor BM and lung transplantation. Methods. Clinical and in vitro data of 26 lung recipients receiving concurrent infusion of donor bone marrow (3.0 to 6.0 x 10 8 cells/kg) were compared with those of 13 patients receiving lung transplant alone. Results. Patient survival and freedom from acute rejection were similar between groups. Of the patients whose graft survived greater than 4 months, 5% (1 of 22) of BM and 33% (4 of 12) of control patients, developed histologic evidence of OB (p = 0.04). A higher proportion (but not statistically significant) of BM recipients (7 of 10, 70%) exhibited donor-specific hyporeactivity by mixed lymphocyte reaction assays as compared with the controls (2 of 7, 28%). Conclusions. Infusion of donor BM at the time of lung transplantation is safe, and is associated with recipients' immune modulation and a lower rate of obliterative bronchiolitis. (C) 2000 by The Society of Thoracic Surgeons.


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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Pham, SM
Rao, AS
Zeevi, A
McCurry, KR
Keenan, RJ
Vega, JD
Kormos, RLkormos@pitt.eduKORMOS
Hattler, BG
Fung, JJ
Starzl, TEtes11@pitt.eduTES11
Griffith, BP
Centers: Other Centers, Institutes, or Units > Thomas E. Starzl Transplantation Institute
Date: 1 February 2000
Date Type: Publication
Journal or Publication Title: Annals of Thoracic Surgery
Volume: 69
Number: 2
Page Range: 345 - 350
DOI or Unique Handle: 10.1016/s0003-4975(99)01471-x
Institution: University of Pittsburgh
Refereed: Yes
ISSN: 0003-4975
Other ID: uls-drl:31735062120203, Starzl CV No. 2108
Date Deposited: 08 Apr 2010 17:36
Last Modified: 13 Oct 2017 17:55
URI: http://d-scholarship.pitt.edu/id/eprint/5494

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