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Detection of infectious baboon cytomegalovirus after baboon-to-human liver xenotransplantation

Michaels, MG and Jenkins, FJ and St. George, K and Nalesnik, MA and Starzl, TE and Rinaldo, J (2001) Detection of infectious baboon cytomegalovirus after baboon-to-human liver xenotransplantation. Journal of Virology, 75 (6). 2825 - 2828. ISSN 0022-538X

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Xenotransplantation is considered to be a solution for the human donor shortage. However, there is a potential risk of transmitting animal infections from the transplanted organ. The known transmissibility and clinical significance of human cytomegalovirus (HCMV) infection after allotransplantation led us to evaluate whether baboon cytomegalovirus (BCMV) transmission could occur after a baboon-to-human liver xenotransplant. We examined serial blood samples from a baboon liver recipient and isolated replication-competent CMV-like agents on days 29, 36, and 42 after xenotransplantation. BCMV and HCMV DNAs were detected in the day 29 isolate, while only HCMV DNA was detected in the other isolates. This is the first report of detecting a replication-competent virus from a source animal after xenotransplantation and is a concern with regard to potential zoonotic transmission to others.


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Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Michaels, MG
Jenkins, FJfjenkins@pitt.eduFJENKINS
St. George, K
Nalesnik, MAnalesnik@pitt.eduNALESNIK
Starzl, TEtes11@pitt.eduTES11
Rinaldo, J
Centers: Other Centers, Institutes, Offices, or Units > Thomas E. Starzl Transplantation Institute
Date: 13 March 2001
Date Type: Publication
Journal or Publication Title: Journal of Virology
Volume: 75
Number: 6
Page Range: 2825 - 2828
DOI or Unique Handle: 10.1128/jvi.75.6.2825-2828.2001
Institution: University of Pittsburgh
Refereed: Yes
ISSN: 0022-538X
Other ID: uls-drl:31735062120609, Starzl CV No. 2148
Date Deposited: 08 Apr 2010 17:36
Last Modified: 03 Aug 2020 14:55


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