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Pancreas and islet cell transplantation

Bottino, R and Trucco, M and Balamurugan, AN and Starzl, TE (2002) Pancreas and islet cell transplantation. Bailliere's Best Practice and Research in Clinical Gastroenterology, 16 (3). 457 - 474. ISSN 1521-6918

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Currently, for the patient with type 1 diabetes, a definitive treatment without resorting to the use of exogenous insulin can be achieved only with pancreas or islet cell transplantation. These means of restoring β-cell mass can completely maintain essentially normal long-term glucose homeostasis, although the need for powerful immunosuppressive regimens limits their application to only a subgroup of adult patients. Apart from the shortage of donors that has limited all kinds of transplantation, however, the widespread use of β-cell replacement has been precluded until recently by the drawbacks associated with both organ and islet cell transplantation. Although the study of recurrence of diabetes has generated attention, the fundamental obstacle to pancreas and islet transplantation has been, and remains, the alloimmune response. With a better elucidation of the mechanisms of alloengraftment achieved during the last 3 years, the stage has been set for further advances.


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Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Bottino, R
Trucco, Mmnt@pitt.eduMNT
Balamurugan, AN
Starzl, TEtes11@pitt.eduTES11
Centers: Other Centers, Institutes, Offices, or Units > Thomas E. Starzl Transplantation Institute
Date: 1 January 2002
Date Type: Publication
Journal or Publication Title: Bailliere's Best Practice and Research in Clinical Gastroenterology
Volume: 16
Number: 3
Page Range: 457 - 474
DOI or Unique Handle: 10.1053/bega.2002.0318
Institution: University of Pittsburgh
Refereed: Yes
ISSN: 1521-6918
Other ID: uls-drl:31735062120849, Starzl CV No. 2172
Date Deposited: 08 Apr 2010 17:37
Last Modified: 04 Feb 2019 15:58


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