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Lessons of organ-induced tolerance learned from historical clinical experience

Starzl, TE and Murase, N and Demetris, AJ and Trucco, M and Abu-Elmagd, K and Gray, EA and Eghtesad, B and Shapiro, R and Marcos, A and Fung, JJ (2004) Lessons of organ-induced tolerance learned from historical clinical experience. Transplantation, 77 (6). 926 - 929. ISSN 0041-1337

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Abstract

Although the reductionist approach has served science well for 400 years, the accumulation of details can obscure the truth if the original premise is incorrect. One such premise has been that successful organ transplantation and bone marrow engraftment are fundamentally different outcomes involving separate and distinct mechanisms. Some historical clinical observations pointed to a different conclusion almost from the beginning and included clues about how to induce tolerance with the aid of immunosuppression.


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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Starzl, TEtes11@pitt.eduTES11
Murase, N
Demetris, AJ
Trucco, M
Abu-Elmagd, K
Gray, EA
Eghtesad, B
Shapiro, R
Marcos, A
Fung, JJ
Centers: Other Centers, Institutes, or Units > Thomas E. Starzl Transplantation Institute
Date: 27 March 2004
Date Type: Publication
Journal or Publication Title: Transplantation
Volume: 77
Number: 6
Page Range: 926 - 929
DOI or Unique Handle: 10.1097/01.tp.0000117780.74133.74
Institution: University of Pittsburgh
Refereed: Yes
ISSN: 0041-1337
Article Type: Review
Other ID: uls-drl:31735062120955, Starzl CV No. 2185
Date Deposited: 08 Apr 2010 17:37
Last Modified: 13 Oct 2017 22:59
URI: http://d-scholarship.pitt.edu/id/eprint/5571

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