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Pancreatic transplantation at the University of Pittsburgh.

Thai, NL and Abu-Elmagd, K and Khan, A and Bond, G and Basu, A and Tom, K and Mazariegos, G and Sindhi, R and Reyes, J and Tan, HP and Marcos, A and Starzl, TE and Shapiro, R (2004) Pancreatic transplantation at the University of Pittsburgh. Clinical transplants. 205 - 214. ISSN 0890-9016

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Campath-1H preconditioning with tacrolimus monotherapy is an effective immunosuppressive regimen for pancreas transplantation, with acceptable patient and graft survival rates early after transplantation. Rejection rates are low under this protocol if the tacrolimus level is kept consistently >10 ng/ml. This immunosuppressive protocol, combined with recent technical refinements, has resulted in lower rates of thrombosis and overall complications. Pancreatic transplantation en-bloc with visceral grafts has the following unique features: Diabetes is a rare indication, and HLA matching is not required. The gland is immunologically protected by the simultaneously transplanted visceral organs. Disease gravity, surgical complexity and gut alloimmunity influence the overall pancreatic allograft survival. The current UNOS listing criteria and data registry should be modified for obvious logistic and scientific reasons.


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Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Thai, NL
Abu-Elmagd, K
Khan, A
Bond, G
Basu, A
Tom, K
Mazariegos, G
Sindhi, Rrsindhi@pitt.eduRSINDHI
Reyes, J
Tan, HP
Marcos, A
Starzl, TEtes11@pitt.eduTES11
Shapiro, R
Centers: Other Centers, Institutes, Offices, or Units > Thomas E. Starzl Transplantation Institute
Date: 1 January 2004
Date Type: Publication
Journal or Publication Title: Clinical transplants
Page Range: 205 - 214
Institution: University of Pittsburgh
Refereed: Yes
ISSN: 0890-9016
Other ID: uls-drl:31735062121235, Starzl CV No. 2213
PubMed ID: 16704151
Date Deposited: 08 Apr 2010 17:38
Last Modified: 18 Feb 2019 16:55


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