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Acute rejection is associated with antibodies to non-Gal antigens in baboons using Gal-knockout pig kidneys

Chen, G and Qian, H and Starzl, T and Sun, H and Garcia, B and Wang, X and Wise, Y and Liu, Y and Xiang, Y and Copeman, L and Liu, W and Jevnikar, A and Wall, W and Cooper, DKC and Murase, N and Dai, Y and Wang, W and Xiong, Y and White, DJ and Zhong, R (2005) Acute rejection is associated with antibodies to non-Gal antigens in baboons using Gal-knockout pig kidneys. Nature Medicine, 11 (12). 1295 - 1298. ISSN 1078-8956

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Abstract

We transplanted kidneys from α1,3-galactosyltransferase knockout (GalT-KO) pigs into six baboons using two different immunosuppressive regimens, but most of the baboons died from severe acute humoral xenograft rejection. Circulating induced antibodies to non-Gal antigens were markedly elevated at rejection, which mediated strong complement-dependent cytotoxicity against GalT-KO porcine target cells. These data suggest that antibodies to non-Gal antigens will present an additional barrier to transplantation of organs from GalT-KO pigs to humans. © 2005 Nature Publishing Group.


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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Chen, G
Qian, H
Starzl, Ttes11@pitt.eduTES11
Sun, H
Garcia, B
Wang, X
Wise, Y
Liu, Y
Xiang, Y
Copeman, L
Liu, W
Jevnikar, A
Wall, W
Cooper, DKC
Murase, N
Dai, Y
Wang, W
Xiong, Y
White, DJ
Zhong, R
Centers: Other Centers, Institutes, or Units > Thomas E. Starzl Transplantation Institute
Date: 1 December 2005
Date Type: Publication
Journal or Publication Title: Nature Medicine
Volume: 11
Number: 12
Page Range: 1295 - 1298
DOI or Unique Handle: 10.1038/nm1330
Institution: University of Pittsburgh
Refereed: Yes
ISSN: 1078-8956
Other ID: uls-drl:31735062121318, Starzl CV No. 2221
Date Deposited: 08 Apr 2010 17:38
Last Modified: 12 Oct 2017 08:55
URI: http://d-scholarship.pitt.edu/id/eprint/5607

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