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Generation of cloned transgenic pigs rich in omega-3 fatty acids

Lai, L and Kang, JX and Li, R and Wang, J and Witt, WT and Hwan, YY and Hao, Y and Wax, DM and Murphy, CN and Rieke, A and Samuel, M and Linville, ML and Korte, SW and Evans, RW and Starzl, TE and Prather, RS and Dai, Y (2006) Generation of cloned transgenic pigs rich in omega-3 fatty acids. Nature Biotechnology, 24 (4). 435 - 436. ISSN 1087-0156

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Abstract

Meat products are generally low in omega-3 (n-3) fatty acids, which are beneficial to human health. We describe the generation of cloned pigs that express a humanized Caenorhabditis elegans gene, fat-1, encoding an n-3 fatty acid desaturase. The hfat-1 transgenic pigs produce high levels of n-3 fatty acids from n-6 analogs, and their tissues have a significantly reduced ratio of n-6/n-3 fatty acids (P < 0.001). © 2006 Nature Publishing Group.


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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Lai, L
Kang, JX
Li, R
Wang, J
Witt, WT
Hwan, YY
Hao, Y
Wax, DM
Murphy, CN
Rieke, A
Samuel, M
Linville, ML
Korte, SW
Evans, RWrwe2@pitt.eduRWE2
Starzl, TEtes11@pitt.eduTES11
Prather, RS
Dai, Y
Centers: Other Centers, Institutes, or Units > Thomas E. Starzl Transplantation Institute
Date: 1 April 2006
Date Type: Publication
Journal or Publication Title: Nature Biotechnology
Volume: 24
Number: 4
Page Range: 435 - 436
DOI or Unique Handle: 10.1038/nbt1198
Institution: University of Pittsburgh
Refereed: Yes
ISSN: 1087-0156
Other ID: uls-drl:31735062121359, Starzl CV No. 2225
Date Deposited: 08 Apr 2010 17:38
Last Modified: 12 Oct 2017 09:56
URI: http://d-scholarship.pitt.edu/id/eprint/5611

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