Shapiro, R and Basu, A and Tan, HP and Morgan, C and Sharma, V and Blisard, D and Randhawa, PS and Dvorchik, I and McCauley, J and Ellis, D and Marsh, JW and Webber, S and Kurland, G and McCurry, KR and Abu-Elmagd, K and Mazariegos, G and Starzl, TE
(2009)
Kidney after nonrenal transplantation-the impact of alemtuzumab induction.
Transplantation, 88 (6).
799 - 802.
ISSN 0041-1337
Abstract
BACKGROUND.: Calcineurin inhibitor nephrotoxicity in nonrenal allograft recipients can lead to end-stage renal disease and the need for kidney transplantation. We sought to evaluate the role of alemtuzumab induction in this population. PATIENTS AND METHODS.: We evaluated 144 patients undergoing kidney transplantation after nonrenal transplantation between May 18, 1998, and October 8, 2007. Seventy-two patients transplanted between January 15, 2003, and October 8, 2007, received alemtuzumab induction and continued their pretransplant immunosuppression. Seventy-two patients transplanted between May 18, 1998, and July 21, 2007, did not receive alemtuzumab induction, but received additional steroids and maintenance immunosuppression. Donor and recipient demographics were comparable. RESULTS.: Overall, 1-and 3-year patient survival and renal function were comparable between the two groups. One-and 3-year graft survival was 93.0% and 75.3% in the alemtuzumab group and 83.3% and 68.7% in the no alemtuzumab group, respectively (P=0.051). The incidence of acute rejection was lower in the alemtuzumab group, 15.3%, than in the no alemtuzumab group, 41.7% (P=0.0001). The incidence of delayed graft function was lower in the alemtuzumab group, 9.7%, than in the no alemtuzumab group, 25.0% (P=0.003). The incidence of viral complications was comparable. CONCLUSION.: Alemtuzumab induction with simple resumption of baseline immunosuppression in patients undergoing kidney transplantation after nonrenal transplantation represents a reasonable immunosuppressive strategy. Copyright © 2009 by Lippincott Williams & Wilkins.
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| Item Type: |
Article
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| Status: |
Published |
| Creators/Authors: |
| Creators | Email | Pitt Username | ORCID  |
|---|
| Shapiro, R | | | | | Basu, A | | | | | Tan, HP | | | | | Morgan, C | | | | | Sharma, V | | | | | Blisard, D | dmb27@pitt.edu | DMB27 | | | Randhawa, PS | | | | | Dvorchik, I | | | | | McCauley, J | | | | | Ellis, D | | | | | Marsh, JW | | | | | Webber, S | | | | | Kurland, G | | | | | McCurry, KR | | | | | Abu-Elmagd, K | | | | | Mazariegos, G | | | | | Starzl, TE | tes11@pitt.edu | TES11 | |
|
| Centers: |
Other Centers, Institutes, Offices, or Units > Thomas E. Starzl Transplantation Institute |
| Date: |
5 November 2009 |
| Date Type: |
Publication |
| Journal or Publication Title: |
Transplantation |
| Volume: |
88 |
| Number: |
6 |
| Page Range: |
799 - 802 |
| DOI or Unique Handle: |
10.1097/tp.0b013e3181b4aaf5 |
| Institution: |
University of Pittsburgh |
| Refereed: |
Yes |
| ISSN: |
0041-1337 |
| Other ID: |
uls-drl:31735062121607, Starzl CV No. 2248 |
| PubMed ID: |
19920779 |
| Date Deposited: |
08 Apr 2010 17:38 |
| Last Modified: |
11 Aug 2022 15:55 |
| URI: |
http://d-scholarship.pitt.edu/id/eprint/5634 |
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