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Thomas, Kristina (2012) THERAPEUTIC DEVELOPMENT FOR CYSTIC FIBROSIS. Master's Thesis, University of Pittsburgh. (Unpublished)

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This thesis considers the aspects of therapeutics development for Cystic Fibrosis (CF). The studies are directed at the development of a new therapeutic outcome measurement for evaluating the performance of CF medications. This imaging-based outcome measures the absorption of a small-molecular radiopharmaceutical, Diethylene triamine pentaacetic acid (DTPA) from the airways as a surrogate measure of liquid absorption. Airway liquid hyper-absorption is a key aspect of CF lung disease that would be expected to correct rapidly after administration of a successful therapy. In vivo pilot studies of this technique have been previously performed at our center [1]. Here we report the results of in vitro studies performed to better define the mechanism underpinning our method and define its utility and limitations.


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Item Type: University of Pittsburgh ETD
Status: Unpublished
CreatorsEmailPitt UsernameORCID
Thomas, Kristinakmt12@pitt.eduKMT12
ETD Committee:
TitleMemberEmail AddressPitt UsernameORCID
Thesis AdvisorCorcoran, Timothy ECorcoranTE@upmc.eduTEC23
Committee MemberParker, Robert SRParker@engr.pitt.eduRPARKER
Committee MemberEnick, Robert Menick@engr.pitt.eduRME
Committee MemberLittle, Steven Rsrlittle@pitt.eduSRLITTLE
Date: 2 February 2012
Date Type: Publication
Defense Date: 13 July 2011
Approval Date: 2 February 2012
Submission Date: 9 November 2011
Access Restriction: No restriction; Release the ETD for access worldwide immediately.
Number of Pages: 44
Institution: University of Pittsburgh
Schools and Programs: Swanson School of Engineering > Chemical Engineering
Degree: MS - Master of Science
Thesis Type: Master's Thesis
Refereed: Yes
Uncontrolled Keywords: DTPA, biomarkers, CF
Date Deposited: 02 Feb 2012 13:42
Last Modified: 19 Dec 2016 14:34


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