Thomas, Kristina
(2012)
THERAPEUTIC DEVELOPMENT FOR CYSTIC FIBROSIS.
Master's Thesis, University of Pittsburgh.
(Unpublished)
Abstract
This thesis considers the aspects of therapeutics development for Cystic Fibrosis (CF). The studies are directed at the development of a new therapeutic outcome measurement for evaluating the performance of CF medications. This imaging-based outcome measures the absorption of a small-molecular radiopharmaceutical, Diethylene triamine pentaacetic acid (DTPA) from the airways as a surrogate measure of liquid absorption. Airway liquid hyper-absorption is a key aspect of CF lung disease that would be expected to correct rapidly after administration of a successful therapy. In vivo pilot studies of this technique have been previously performed at our center [1]. Here we report the results of in vitro studies performed to better define the mechanism underpinning our method and define its utility and limitations.
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Details
| Item Type: |
University of Pittsburgh ETD
|
| Status: |
Unpublished |
| Creators/Authors: |
|
| ETD Committee: |
|
| Date: |
2 February 2012 |
| Date Type: |
Publication |
| Defense Date: |
13 July 2011 |
| Approval Date: |
2 February 2012 |
| Submission Date: |
9 November 2011 |
| Access Restriction: |
No restriction; Release the ETD for access worldwide immediately. |
| Number of Pages: |
44 |
| Institution: |
University of Pittsburgh |
| Schools and Programs: |
Swanson School of Engineering > Chemical Engineering |
| Degree: |
MS - Master of Science |
| Thesis Type: |
Master's Thesis |
| Refereed: |
Yes |
| Uncontrolled Keywords: |
DTPA, biomarkers, CF |
| Date Deposited: |
02 Feb 2012 13:42 |
| Last Modified: |
19 Dec 2016 14:34 |
| URI: |
http://d-scholarship.pitt.edu/id/eprint/6235 |
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