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Vocal Fold Fibroblast Response to Mechanical Stress

Branski, Ryan C (2005) Vocal Fold Fibroblast Response to Mechanical Stress. Doctoral Dissertation, University of Pittsburgh. (Unpublished)

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The role of exercise in vocal fold wound healing has been overlooked. Data from numerous other systems suggest a positive role of tissue mobilization to facilitate optimal wound healing and biomechanically superior tissue. The current study sought to investigate the potential role of mechanical signaling to attenuate the inflammatory and alter the synthetic properties of fibroblasts cultured from the vocal folds. Vocal fold fibroblasts were subjected to one of four conditions: no treatment, IL-1â alone, mechanical stress alone, or mechanical stress plus IL-1â. Results suggest that mechanical stress may limit the inflammatory phenotype of vocal fold fibroblasts in the short-term (4 hours), but not in the long-term (24 hours). In fact, 24 hours of mechanical stress may actually increase the inflammatory response. In addition, neither IL-1â nor mechanical stress had an effect on vocal fold fibroblast synthesis of extracellular matrix proteins. As a potential explanation for the current findings, it is hypothesized that the vocal folds may be more resilient to mechanical stress given the inherently stressful environment associated with phonation.


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Item Type: University of Pittsburgh ETD
Status: Unpublished
CreatorsEmailPitt UsernameORCID
Branski, Ryan Crcb2@pitt.eduRCB2
ETD Committee:
TitleMemberEmail AddressPitt UsernameORCID
Committee ChairVerdolini, Katherinekittie@csd.pitt.eduKAV25
Committee MemberRosen, Clark A.rosenca@upmc.eduCROSEN
Committee MemberHebda, Patricia
Committee MemberAgarwal,
Committee MemberShaiman, Susanshaiman@csd.pitt.eduSHAIMAN
Date: 17 March 2005
Date Type: Completion
Defense Date: 7 February 2005
Approval Date: 17 March 2005
Submission Date: 7 March 2005
Access Restriction: No restriction; Release the ETD for access worldwide immediately.
Institution: University of Pittsburgh
Schools and Programs: School of Health and Rehabilitation Sciences > Communication Science and Disorders
Degree: PhD - Doctor of Philosophy
Thesis Type: Doctoral Dissertation
Refereed: Yes
Uncontrolled Keywords: cyclic tensile strain; extracellular matrix; fibroblast; inflammation; vocal fold
Other ID:, etd-03072005-162623
Date Deposited: 10 Nov 2011 19:32
Last Modified: 19 Dec 2016 14:35


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