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Decision Aid to Determine the Necessity of Right Ventricular Support for Patients Receiving a Left Ventricular Assist Device

Uber, Bronwyn (2006) Decision Aid to Determine the Necessity of Right Ventricular Support for Patients Receiving a Left Ventricular Assist Device. Master's Thesis, University of Pittsburgh. (Unpublished)

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The purpose of this study was to improve the efficacy of VAD therapy for patients intended for VAD insertion. The study focused on the specific decision whether an LVAD or BiVAD is appropriate. A hierarchical decision model was constructed using an influence diagram of clinical risk factors derived through interviews with expert cardiologists and cardiac surgeons. Most of the variables are summarized by two independent criteria: risk of surgery and risk of right ventricular (RV) failure. These risks are computed from various patient demographics, tests, and hemodynamics using expert physician-selected weighted linear and weighted non-linear relationships. The model was validated with retrospective data from patient records at University of Pittsburgh Medical Center (UPMC) for patients implanted after 1990 and explanted before 2006. In total 239 patients were implanted and explanted during this time, of those 168 had sufficient information to be used in this analysis. 48 patients received biventricular assistance (BiVADs), 119 patients received only left ventricular assistance (LVADs). Of these 119 LVAD patients, 19 subsequently received an RVAD due to unanticipated RV dysfunction. Pre-implant data were used as input to the model. The model parameters were derived from two different physicians. The models based on individual physician's weightings predicted 63% (47%) of the patients who required an RVAD after implant. However, these decision models also recommended BiVAD implantation for 40% (43%) of patients who were treated successfully with an LVAD alone.A nonlinear numerical optimizer was used to improve the model parameters to optimize the agreement with eventual outcomes. The optimized model predicted 74% of the patients who required an RVAD post-implant and recommended the implantation of BiVADs in 21% of patients who were treated successfully with an LVAD alone. In conclusion, the decision model provided a more aggressive use of biventricular assistance, which retrospectively would have benefited patients who required an RVAD at a later date, but would have unnecessarily implanted RVADs in some patients that survived with an LVAD alone. However the model also identified that 48% of the patients who initially received BiVADs to be candidates for LVAD alone.


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Item Type: University of Pittsburgh ETD
Status: Unpublished
CreatorsEmailPitt UsernameORCID
ETD Committee:
TitleMemberEmail AddressPitt UsernameORCID
Committee ChairAntaki, James
Committee MemberBorovetz, Harvey Sborovetzhs@upmc.eduBOROVETZ
Committee MemberSimaan, Marwan Asimaan@engr.pitt.eduSIMAAN
Date: 2 June 2006
Date Type: Completion
Defense Date: 29 March 2006
Approval Date: 2 June 2006
Submission Date: 28 March 2006
Access Restriction: No restriction; Release the ETD for access worldwide immediately.
Institution: University of Pittsburgh
Schools and Programs: Swanson School of Engineering > Bioengineering
Degree: MSBeng - Master of Science in Bioengineering
Thesis Type: Master's Thesis
Refereed: Yes
Uncontrolled Keywords: Decision Aid; Patient Selection; Right Ventricle; Ventricular Assist Device
Other ID:, etd-03282006-104153
Date Deposited: 10 Nov 2011 19:33
Last Modified: 19 Dec 2016 14:35


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