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Development of computational mass and momentum transfer models for extracorporeal hollow fiber membrane oxygenators

Gage, Kenneth Leslie (2007) Development of computational mass and momentum transfer models for extracorporeal hollow fiber membrane oxygenators. Doctoral Dissertation, University of Pittsburgh. (Unpublished)

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Simulation of mass and momentum transfer in hollow fiber membrane (HFM) oxygenators has remained a topic of interest for decades. The current work reports upon efforts toward modeling the transport phenomena within these devices using a computational fluid dynamic (CFD) approach. The results and findings form a basis for future efforts in computational model development, design refinement and the investigation of other HFM systems.The main purpose of the present work was to determine the validity and applicability of the Darcian porous media model for three-dimensional flow simulations of a commercial membrane oxygenator design. Close agreement between experiment and simulation was found for pressure losses within the device, although not within the standard deviation of the experimental data. The divergence could be attributed to the governing equations, which incorporated the Darcian model parameters into a less restrictive model, or the model parameters themselves, which were assumed isotropic and uniform.The porous media model developed was used to predict the superficial velocity field of the membrane oxygenator during operation. For model verification, the experimental and CFD-predicted flow fields were compared using optical flow calculations performed on radiographic and simulated radiographic images, respectively. The data obtained were adequate for qualitative but not quantitative comparison and suggested reasonable agreement between experiment and simulation. Methods for improving the data and the interpretation were also described.It was hypothesized that appropriate CFD models would predict the local oxygen concentration and gas exchange in a HFM oxygenator. A mass transfer correlation for a non-reactive fluid was derived using parameters from the literature. The correlation was converted to a reactive form for blood through dimensional analysis and incorporated into a CFD simulation. The results from these simulations and an analysis of the experimental process indicated that the parameters used are subject to error when data collection is performed in a limited flow range.In conclusion, CFD-based simulations hold promise for HFM evaluation and design. Future researchers should consider the appropriateness of models and parameters during simulation development. Proper validation techniques are also critical for model assessment and evaluation.


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Item Type: University of Pittsburgh ETD
Status: Unpublished
CreatorsEmailPitt UsernameORCID
Gage, Kenneth
ETD Committee:
TitleMemberEmail AddressPitt UsernameORCID
Committee ChairWagner, William Rwagnerwr@upmc.eduWAGNER
Committee MemberBoada,
Committee MemberBorovetz, Harvey Sborovetzhs@upmc.eduBOROVETZ
Committee MemberGerlach, Jorg
Committee MemberFederspiel, William Jfederspielwj@upmc.eduWFEDERSP
Date: 12 June 2007
Date Type: Completion
Defense Date: 26 October 2005
Approval Date: 12 June 2007
Submission Date: 28 March 2007
Access Restriction: No restriction; Release the ETD for access worldwide immediately.
Institution: University of Pittsburgh
Schools and Programs: Swanson School of Engineering > Chemical Engineering
Degree: PhD - Doctor of Philosophy
Thesis Type: Doctoral Dissertation
Refereed: Yes
Uncontrolled Keywords: fluoroscopy; artificial lung; membrane oxygenator; optical flow; computational fluid dynamics; flow visualization
Other ID:, etd-03282007-145614
Date Deposited: 10 Nov 2011 19:33
Last Modified: 19 Dec 2016 14:35


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