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Association between infant birth weight, preterm delivery and maternal cardiovascular risk in the Health, Aging and Body Composition Study

Catov, Janet M. (2005) Association between infant birth weight, preterm delivery and maternal cardiovascular risk in the Health, Aging and Body Composition Study. Doctoral Dissertation, University of Pittsburgh. (Unpublished)

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Abstract

Mothers who deliver a low birth weight infant may themselves be at excess risk for cardiovascular disease. We validated maternal recall of infant birth weight after an average follow up of 57 years, and investigated whether older women who reported having delivered low birth weight (LBW) infants (<2500 g) had later elevations in cardiovascular risk factors and were at increased risk for clinical cardiovascular disease. Participants were 446 women (mean age 80 years; 47% black) enrolled in The Health, Aging and Body Composition Study. Women reported birth weight and selected complications for each pregnancy, and pregnancies complicated by hypertension or preeclampsia were excluded. We found strong correlation between recalled and documented birth weights for first births (ICC=0.96) in a randomly selected group of participants, and reliability of recall for first births remained high when considered separately by race, education, income and age. Women who had reported a LBW first birth had a lower current BMI (adjusted for race and age) compared to women with normal weight infants (26.6 vs. 28.0 kg/m²; p=0.057), but they had a higher abdominal circumference (98.1 vs. 95.0 cm; p=0.007). After adjustment for BMI, race and age, women with a history of a LBW vs. normal weight infant had elevated systolic blood pressures (p=0.048) despite higher use of anti-hypertensive medication (p=0.061). Women with LBW infants also had higher levels of IL-6 (p=0.021), fasting insulin (p=0.064), and triglycerides (p=0.071), and they were more insulin resistant (p=0.045) compared to women with a normal weight infant. Women who delivered preterm infants had an elevated risk for cardiovascular disease at age 80 (adjusted odds ratio=2.77, 95% CI 1.06-7.24) compared to women who delivered term infants. Women who had delivered infants both LBW and preterm had markedly elevated cardiovascular risk factors when compared to women with normal weight term infants, and appeared to have the highest risk for clinical cardiovascular disease (adjusted odds ratio=4.21, 95% CI 1.23-14.45). The public health importance of these findings is that a history of LBW or preterm delivery may identify women who would benefit from screening and intervention aimed at risk factors for cardiovascular disease.


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Details

Item Type: University of Pittsburgh ETD
Status: Unpublished
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Catov, Janet M.jcatov@att.net
ETD Committee:
TitleMemberEmail AddressPitt UsernameORCID
Committee ChairNess, Roberta Bnessr@edc.pitt.edu
Committee MemberNewman, Anne Banewman@pitt.eduANEWMAN
Committee MemberRoberts, James MRSIJMR@MWRI.MAGEE.EDU
Committee MemberSutton-Tyrrell, Kim Ctyrrell@edc.pitt.edu
Committee MemberKelsey, Sheryl Fkelsey@edc.pitt.eduKELSEYS
Date: 20 June 2005
Date Type: Completion
Defense Date: 25 February 2005
Approval Date: 20 June 2005
Submission Date: 30 March 2005
Access Restriction: No restriction; Release the ETD for access worldwide immediately.
Institution: University of Pittsburgh
Schools and Programs: Graduate School of Public Health > Epidemiology
Degree: PhD - Doctor of Philosophy
Thesis Type: Doctoral Dissertation
Refereed: Yes
Uncontrolled Keywords: maternal cardiovascular risk; poor pregnancy outcomes; reproductive exposures
Other ID: http://etd.library.pitt.edu/ETD/available/etd-03302005-111246/, etd-03302005-111246
Date Deposited: 10 Nov 2011 19:33
Last Modified: 15 Nov 2016 13:37
URI: http://d-scholarship.pitt.edu/id/eprint/6646

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