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An Evaluation of Psychosocial and Socio-demographic Factors Associated with Metabolic Syndrome and Cardiovascular Risk in Polycystic Ovary Syndrome Cases and Controls

Cipkala-Gaffiin, Janet A. (2009) An Evaluation of Psychosocial and Socio-demographic Factors Associated with Metabolic Syndrome and Cardiovascular Risk in Polycystic Ovary Syndrome Cases and Controls. Doctoral Dissertation, University of Pittsburgh. (Unpublished)

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Background: Major aims of the psychological research in PCOS were: (1) to compare the prevalence of depressive symptoms in women with PCOS to controls; (2) to determine whether depression and psychological traits (anger, anxiety, hostility/cynicism) and satisfaction with life are associated with PCOS (3) to determine the prevalence of Metabolic Syndrome (MS) in PCOS cases and controls (4) to determine if psychological factors are risk factors for Metabolic Syndrome independent of age, marital status, education, and parity (5) to determine if psychological factors, independent of baseline cardiovascular risk factors, are a risk factor for IMT in women with PCOS.Design: Prospective and cross sectional.Methods: Cases (n=161) and controls (n=161) matched on age, race, and neighborhood a subset of the Cardiovascular Health and Risk Measurement study (CHARM) investigating coronary heart disease risk factors in women with PCOS. Psychological measures were Beck Depression Inventory I (BDI I), Speilberger Trait Anger and Anxiety Scales, Cook-Medley Scale, Diener Satisfaction with Life Scale. Results: PCOS women had a higher prevalence of depression (BDI scores > 9; predominately a mild level of depression): 31% vs. 17% in controls (P=.016; OR 1.9; CI 1.55-2.16). Within cases, BMI, education, and parity were statistically significant predictors of depression, p<.05. The odds of being depressed (at least mild severity) increased by 6% for each unit increase of BMI, the odds of being depressed decreased by 20% for each year of education, and the odds of being depressed increased by 44% for parity (per live birth). The odds of having PCOS increased with each unit of BDI score by 1.06 times, adjusting for marital status, BMI, smoking, and education (entire sample).Results from MS, 27% (n=40) of the cases and 9.9% (n=15) of the controls had MS (p<.05; OR 3.4; CI 1.726-6.400. The odds of having MS increased by 10% for each year of age and threefold for PCOS cases.There were no effects from the psychological factors independent baseline cardiovascular risk factors on IMT. Conclusions: Depression is a major psychological concern in PCOS. Public Health Significance: Women with PCOS should be screened on diagnosis and monitored closely for depression.


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Item Type: University of Pittsburgh ETD
Status: Unpublished
CreatorsEmailPitt UsernameORCID
Cipkala-Gaffiin, Janet
ETD Committee:
TitleMemberEmail AddressPitt UsernameORCID
Committee ChairTalbott, Evelyn Oeot1@pitt.eduEOT1
Committee MemberBrown, Charlottechb9@pitt.eduCHB9
Committee MemberBarinas-Mitchell, Emmabarinas@edc.pitt.eduEJB4
Committee MemberWilson, Johnwilson@nsabp.pitt.eduJWW
Committee MemberSong,
Date: 29 June 2009
Date Type: Completion
Defense Date: 24 March 2009
Approval Date: 29 June 2009
Submission Date: 7 April 2009
Access Restriction: 5 year -- Restrict access to University of Pittsburgh for a period of 5 years.
Institution: University of Pittsburgh
Schools and Programs: School of Public Health > Epidemiology
Degree: DrPH - Doctor of Public Health
Thesis Type: Doctoral Dissertation
Refereed: Yes
Uncontrolled Keywords: depression; IMT; polysyctic ovary syndrome
Other ID:, etd-04072009-181007
Date Deposited: 10 Nov 2011 19:34
Last Modified: 15 Nov 2016 13:38


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