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Association Between Hormone Replacement Therapy (HRT) Use and Radiographic Emphysema Risk

Nnadi, Chimeremma (2011) Association Between Hormone Replacement Therapy (HRT) Use and Radiographic Emphysema Risk. Master's Thesis, University of Pittsburgh. (Unpublished)

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Abstract

Emphysema, a form of chronic obstructive pulmonary disease (COPD) is a disease of significant public health importance that remains a major cause of morbidity and mortality within the US population and elsewhere in the industrialized world. An emerging body of literature appears to suggest gender differences in susceptibility to emphysema, with women showing significantly less emphysematous changes on high resolution Computed Tomography radiography compared to men. A pertinent but yet to be addressed question in the literature however, is whether these apparent differences in emphysematous structural lung disease result from differential exposures and or lifestyle choices on the one hand, or if on the other hand, these gender differences in CT-emphysema are related to certain biological mechanisms such as female hormonal influences or genetic differences in toxin metabolism. The present study evaluated differences in CT-emphysema status among 1834 women with different hormone replacement therapy (HRT) exposure profiles. In an unadjusted generalized logistic regression model, current use of HRT was statistically significantly associated with a 38% reduction in the risk of moderate to severe CT-emphysema, OR 0.62 (95% CI=0.39-0.99). After adjusting for the effects of age and smoking dose intensity, current HRT-users had a 34% reduction in the risk of mild to moderate CT-emphysema compared to never-users. Although this effect is quite sizable, it was marginally statistically insignificant, OR=0.66 (95% CI=0.41-1.07). We conclude that current use of hormone replacement therapy may be associated with a lower risk of moderate to severe CT-emphysema.


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Details

Item Type: University of Pittsburgh ETD
Status: Unpublished
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Nnadi, Chimeremmacdn7@pitt.eduCDN7
ETD Committee:
TitleMemberEmail AddressPitt UsernameORCID
Committee ChairWeissfeld, Joel Ljwepid@pitt.eduJWEPID
Committee MemberSiegfried, Jill Mjsiegfr@pitt.eduJSIEGFR
Committee MemberLand, Stephanie Rland@nsabp.pitt.edu
Date: 29 June 2011
Date Type: Completion
Defense Date: 1 April 2011
Approval Date: 29 June 2011
Submission Date: 7 April 2011
Access Restriction: 5 year -- Restrict access to University of Pittsburgh for a period of 5 years.
Institution: University of Pittsburgh
Schools and Programs: Graduate School of Public Health > Epidemiology
Degree: MS - Master of Science
Thesis Type: Master's Thesis
Refereed: Yes
Uncontrolled Keywords: CT-EMPHYSEMA; EMPHYSEMA; ESTROGEN; FEMALE REPRODUCTIVE HORMONES; GENDER DIFFERENCES; HORMONE REPLACEMENT THERAPY; HRT
Other ID: http://etd.library.pitt.edu/ETD/available/etd-04072011-143321/, etd-04072011-143321
Date Deposited: 10 Nov 2011 19:35
Last Modified: 15 Nov 2016 13:38
URI: http://d-scholarship.pitt.edu/id/eprint/6876

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