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Osteoporosis: Identification of Factors Associated with Fracture, Bone Mineral Density, Bone Geometry and Bone Strenth in Older Adults

Barbour, Kamil Elie (2010) Osteoporosis: Identification of Factors Associated with Fracture, Bone Mineral Density, Bone Geometry and Bone Strenth in Older Adults. Doctoral Dissertation, University of Pittsburgh. (Unpublished)

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Osteoporosis is a major public health problem in men and women. Low bone mineral density (BMD) is a major risk factor for fracture. Fractures have major implications for morbidity and mortality. This research project evaluated correlates of trabecular and cortical vBMD at the radius and tibia in primarily Caucasian men aged 69 years or older using the Osteoporotic Fractures in Men study (MrOS). The correlation between serum 25-hydroxy vitamin D [25(OH)D] and bone density, content, geometry and strength was also assessed using Caucasian men from MrOS and men of African descent from the Tobago Bone Health Study, aged 65 years and older. We also investigated the longitudinal impact of serum leptin and adiponectin on bone loss and fractures in the Health Aging and Body Composition study (Health ABC) in men and women, aged 70 years and older, of African American and Caucasian descent. Our findings have important public health implications. We have a better understanding of how different factors are correlated with trabecular and cortical and vBMD. Future research can generate hypotheses to evaluate these associations prospectively. Men of African descent had significantly higher 25(OH)D than Caucasians, which has never been reported. Serum 25(OH)D was positively correlated with indices of bone strength in Caucasian men, but not men of African descent. Serum 25(OH)D thresholds were identified at an estimated 20 ng/ml (lower than previous consensus of 30 ng/ml), greater levels of 25(OH)D had minimal effects on bone measures. Significant correlations between 25(OH)D occurred only at cortical regions. Prospective studies that evaluate the impact of 25(OH)D on trabecular and cortical vBMD loss are needed. There was an association between higher adiponectin and greater risk of incident fracture in men only. We also report that adiponectin predicted greater hip areal BMD (aBMD) loss among women, but not men. The impact of leptin on bone loss and incident fractures was largely attenuated by BMI and weight change. This study provides strong evidence that higher levels of adiponectin may increase the risk of bone loss and fracture. Studies are needed to explain these differential associations for adiponectin in women and men.


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Item Type: University of Pittsburgh ETD
Status: Unpublished
CreatorsEmailPitt UsernameORCID
Barbour, Kamil
ETD Committee:
TitleMemberEmail AddressPitt UsernameORCID
Committee ChairCauley, JaneJCauley@edc.pitt.eduJCAULEY
Committee MemberStrotmeyer, Elsastrotmeyere@edc.pitt.eduELSST21
Committee MemberZmuda, JosephZmudaJ@edc.pitt.eduEPIDJMZ
Committee MemberHorwitz,
Committee MemberEvans, RhobertEvansR@edc.pitt.eduRWE2
Committee MemberBoudreau, RobertBoudreauR@edc.pitt.eduROB21
Date: 28 June 2010
Date Type: Completion
Defense Date: 16 March 2010
Approval Date: 28 June 2010
Submission Date: 8 April 2010
Access Restriction: 5 year -- Restrict access to University of Pittsburgh for a period of 5 years.
Institution: University of Pittsburgh
Schools and Programs: School of Public Health > Epidemiology
Degree: PhD - Doctor of Philosophy
Thesis Type: Doctoral Dissertation
Refereed: Yes
Uncontrolled Keywords: DXA; pQCT; BMD; Osteoporosis
Other ID:, etd-04082010-183309
Date Deposited: 10 Nov 2011 19:35
Last Modified: 15 Nov 2016 13:39


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