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A Model of Bacterial Superinfection in an Influenza-Infected Host

Linn, Sherry (2011) A Model of Bacterial Superinfection in an Influenza-Infected Host. Master's Thesis, University of Pittsburgh. (Unpublished)

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Abstract

Bacterial pneumonia is a common complication of influenza A infection. We create an ODE model of bacterial infection with state variables representing the respective levels of bacteria, impaired and active neutrophils, and the anti-inflammatory molecule interleukin 10 (IL-10). After fitting the parameters, we obtain a model that demonstrates bistability between states of health and chronic bacterial infection. The fitted model also closely reproduces IL-10 data obtained from a model of mice inoculated with a strain of influenza A virus. Additionally, we develop a different model similar to the first but with stochastic intake of bacteria to represent the inhalation of small amounts of bacteria into the lungs many times daily. We find a set of parameters for which the second model produces a fit to the IAV IL-10 data.

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Details

Item Type: University of Pittsburgh ETD
Status: Unpublished
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Linn, Sherrysbl6@pitt.eduSBL6
ETD Committee:
TitleMemberEmail AddressPitt UsernameORCID
Committee ChairSwigon, David swigon@pitt.eduSWIGON
Committee MemberErmentrout, G Bardbard@pitt.eduBARD
Committee MemberClermont, Gillesclermontg@ccm.upmc.edu
Committee MemberRubin, Jonathanjonrubin@pitt.eduJONRUBIN
Date: 6 June 2011
Date Type: Completion
Defense Date: 18 March 2011
Approval Date: 6 June 2011
Submission Date: 11 April 2011
Access Restriction: No restriction; Release the ETD for access worldwide immediately.
Institution: University of Pittsburgh
Schools and Programs: Dietrich School of Arts and Sciences > Mathematics
Degree: MS - Master of Science
Thesis Type: Master's Thesis
Refereed: Yes
Uncontrolled Keywords: inflammation; mathematical model
Other ID: http://etd.library.pitt.edu/ETD/available/etd-04112011-115917/, etd-04112011-115917
Date Deposited: 10 Nov 2011 19:35
Last Modified: 15 Nov 2016 13:39
URI: http://d-scholarship.pitt.edu/id/eprint/7023

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