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Berkowitz, Jennifer Lee (2007) EXHALED GAS AS A NON-INVASIVE MARKER FOR AIRWAY INFLAMMATION IN PATIENTS WITH CYSTIC FIBROSIS. Master's Thesis, University of Pittsburgh. (Unpublished)

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Cystic Fibrosis (CF) is the most commonly inherited, life-shortening genetic condition amongst Caucasians, with an incidence of about 1 in 3,800 newborns and currently affecting about 30,000 Americans. It is chronically debilitating and the annual cost of medical care per person makes it a serious public health concern. Airway inflammation contributes to progressive pulmonary disease, the leading cause of morbidity and mortality in patients with Cystic Fibrosis. The mechanism by which the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) gene affects airway inflammation has not been fully elucidated to date; however, several mechanisms have been proposed. Despite the need for continued study in determining this mechanism, we do know that mutations in the CFTR gene ultimately result in bacterial colonization in the lungs, reduced mucociliary clearance and airway inflammation. Chronic airway inflammation results in continued assault on the lungs and progresses the course of the disease. Airway inflammation can be monitored through the use of bronchoalveolar lavage to evaluate the influx of neutrophils; however, routine bronchoscopy is an invasive procedure and is less than ideal for routine assessment. Exhaled gas as a marker for airway inflammation is useful in that it is minimally invasive and relatively easy to obtain. Some of the data on the clinical utility of exhaled gas measurements has been conflicting with regard to its efficacy in assessing airway inflammation. If exhaled gas measurements can be used to assess airway inflammation, they could provide a non-invasive alternative to monitor inflammation and do so more frequently than invasive methods, with the ultimate goal of being able to detect inflammation earlier with the intent of earlier treatment and possible reduction in progression of lung disease.


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Item Type: University of Pittsburgh ETD
Status: Unpublished
CreatorsEmailPitt UsernameORCID
Berkowitz, Jennifer
ETD Committee:
TitleMemberEmail AddressPitt UsernameORCID
Committee ChairGettig, Elizabeth
Committee CoChairPilewski, Joseph M
Committee MemberGollin, Susanne M
Date: 29 June 2007
Date Type: Completion
Defense Date: 10 April 2007
Approval Date: 29 June 2007
Submission Date: 12 April 2007
Access Restriction: 5 year -- Restrict access to University of Pittsburgh for a period of 5 years.
Institution: University of Pittsburgh
Schools and Programs: School of Public Health > Genetic Counseling
Degree: MS - Master of Science
Thesis Type: Master's Thesis
Refereed: Yes
Uncontrolled Keywords: inflammatory response; non-invasive markers for airway inflammation; innate immune response; mucociliary clearance; pulmonary exacerbations
Other ID:, etd-04122007-181056
Date Deposited: 10 Nov 2011 19:36
Last Modified: 15 Nov 2016 13:39


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