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Evaluation of the Biaxial Mechanical Properties of the Mitral Valve Anterior Leaflet Under Physiological Loading Conditions

Grashow, Jonathan Sayer (2005) Evaluation of the Biaxial Mechanical Properties of the Mitral Valve Anterior Leaflet Under Physiological Loading Conditions. Master's Thesis, University of Pittsburgh. (Unpublished)

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It is a fundamental assumption that a repaired mitral valve (MV) or MV replacement should mimic the functionality of the native MV as closely as possible. Thus, improvements in valvular treatments are dependent on the establishment of a complete understanding of the mechanical properties of the native MV. In this work, the biaxial mechanical properties, including the viscoelastic properties, of the MV anterior leaflet (MVAL) were explored. A novel high-speed biaxial testing device was developed to achieve stretch rates both below and beyond in-vitro values reported for the MVAL (Sacks et al, ABME, Vol. 30,pp. 1280-90, 2002). Experiments were performed with this device to assess the effects of stretch rate (from quasi-static to physiologic) on the stress-stretch response in the native leaflet. Additionally, stress-relaxation and creep tests were performed on the MVAL under physiologic biaxial loading conditions.The results of these tests showed that the stress-stretch responses of the MVAL during the loading phases were remarkably independent of stretch rate. The results of the creep and relaxation experiments revealed that the leaflet exhibited significant relaxation, but unlike traditional viscoelastic biological materials, exhibited negligible creep.These results suggested that the MVAL may be functionally modeled as an anisotropic quasi-elastic material and highlighted the importance of performing creep experiments on soft tissues. Additionally, this study underscored the necessity of performing biaxial experiments in order to appropriately determine the mechanical properties of membranous tissues.


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Item Type: University of Pittsburgh ETD
Status: Unpublished
CreatorsEmailPitt UsernameORCID
Grashow, Jonathan Sayerjsgst29@pitt.eduJSGST29
ETD Committee:
TitleMemberEmail AddressPitt UsernameORCID
Committee ChairSacks,
Committee MemberNagatomi, Jironagatomi@pitt.eduNAGATOMI
Committee MemberDebski, Richardrdebski@engr.pitt.eduGENESIS1
Date: 20 June 2005
Date Type: Completion
Defense Date: 12 April 2005
Approval Date: 20 June 2005
Submission Date: 13 April 2005
Access Restriction: No restriction; Release the ETD for access worldwide immediately.
Institution: University of Pittsburgh
Schools and Programs: Swanson School of Engineering > Bioengineering
Degree: MSBeng - Master of Science in Bioengineering
Thesis Type: Master's Thesis
Refereed: Yes
Uncontrolled Keywords: biaxial testing; heart valve; mitral valve; soft tissue
Other ID:, etd-04132005-201559
Date Deposited: 10 Nov 2011 19:36
Last Modified: 15 Nov 2016 13:40


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