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IMPLEMENTATION OF THE HARDY-WEINBERG TEST FOR EQUILIBRIUM IN A STUDY EXAMINING THE RELATIONSHIP BETWEEN THE DOPAMINE TRANSPORTER GENE (SCL6A3) AND SMOKING CESSATION IN WOMEN

Leon-Verdin, MaGuadalupe (2007) IMPLEMENTATION OF THE HARDY-WEINBERG TEST FOR EQUILIBRIUM IN A STUDY EXAMINING THE RELATIONSHIP BETWEEN THE DOPAMINE TRANSPORTER GENE (SCL6A3) AND SMOKING CESSATION IN WOMEN. Master's Thesis, University of Pittsburgh. (Unpublished)

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Abstract

The dopamine transporter gene is an untranslated polymorphic region, which consists of a replication of 40-base pairs. The locus of this 3' variable number tandem repeat (VNTR) polymorphism is on 5p15.3 and repeats from 3 to 13 times. In most populations, the most common alleles are 9 and 10. The distribution of the dopamine transporter genotypes also varies among races.These genotypes have been shown to be associated with different conditions of health such as smoking status, obesity and food intake. Nine-carriers have been associated with late initiation of smoking. Homozygous for SCL6A3 - 10 are related to have higher concentration of dopamine transporter protein and to have lower postsynaptic concentration of dopamine. In this paper, the role of the SCL6A3 genotypes and allele carriers are investigated in a sample of women smokers willing to quit smoking who are concerned with postcessation weight gain. Because of the small number of women carrying alleles other than 9 or 10 allele, the sample size was limited to three genotypes. The main purpose of this work is to test departure from Hardy-Weinberg Equilibrium.The result shows that the proportions of the genotype were p^2, 2pq, and q^2; therefore, this gene is in Hardy-Weinberg Equilibrium. The genotype proportions in Caucasian women were similar to those previously reported in European-Caucasian women, and the proportions in African-American women were similar to previously reported literature values among African-American. These findings could have public health relevance in smoking cessation programs.


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Details

Item Type: University of Pittsburgh ETD
Status: Unpublished
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Leon-Verdin, MaGuadalupemal71@pitt.edu and lupitalv2001@hotmail.com
ETD Committee:
TitleMemberEmail AddressPitt UsernameORCID
Committee ChairWeissfeld, Lisalweis@pitt.eduLWEIS
Committee MemberKong, Lanlkong@pitt.eduLKONG
Committee MemberLevine, Michele Dlevinem@upmc.eduMLEVINE
Date: 26 June 2007
Date Type: Completion
Defense Date: 13 April 2007
Approval Date: 26 June 2007
Submission Date: 13 April 2007
Access Restriction: No restriction; Release the ETD for access worldwide immediately.
Institution: University of Pittsburgh
Schools and Programs: Graduate School of Public Health > Biostatistics
Degree: MS - Master of Science
Thesis Type: Master's Thesis
Refereed: Yes
Uncontrolled Keywords: Hardy-Weinberg equilibrium; smoking cessation; dopamine transporter gene; polymorphism
Other ID: http://etd.library.pitt.edu/ETD/available/etd-04132007-212405/, etd-04132007-212405
Date Deposited: 10 Nov 2011 19:37
Last Modified: 19 Dec 2016 14:35
URI: http://d-scholarship.pitt.edu/id/eprint/7115

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