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Biofuel Cells as a Possible Power Source for Implantable Electronic Devices

Justin, Gusphyl Antonio (2004) Biofuel Cells as a Possible Power Source for Implantable Electronic Devices. Master's Thesis, University of Pittsburgh.

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    Abstract

    A major challenge facing the development of implantable devices for clinical use is in finding a suitable power source for such devices. The power source should be able to generate an electric current for extended periods of time. Biofuel cells (BFC) provide some promise in this respect, as their function is primarily based on coupling the oxidation of glucose to the reduction of molecular oxygen to water. Under ideal conditions, the only byproducts of the BFC would simply be carbon dioxide and water. Both glucose and oxygen are present in the cells and tissues of all eukaryotic organisms, including human beings. It might, therefore, be possible to tap into the body's own resources, including the metabolic properties of our cells, to generate enough energy to power an array of clinical devices. The experiments described in this paper serve as a first step toward the goal of designing a BFC that would be based on transducing the power of oxidative metabolism within our own cells into an electrical current. In the first phase of our experiments, the function and current output of a specific type of BFC, called a microbial fuel cell (MFC)is investigated. The behavior and characteristics of such biofuel cells have been well documented in the scientific literature. MFCs essentially convert the biochemical energy of bacteria into electrical energy. A strain of E. Coli is used in our study. In the second phase of our experiments, an attempt is made to derive electrical currents from BFCs employing human white blood cells.


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    Item Type: University of Pittsburgh ETD
    ETD Committee:
    ETD Committee TypeCommittee MemberEmail
    Committee ChairSun, Minguimrsun@neuronet.pitt.edu
    Committee MemberBorovetz, Harveyborovetzhs@msx.upmc.edu
    Committee MemberSclabassi, Robertbobs@neuronet.pitt.edu
    Title: Biofuel Cells as a Possible Power Source for Implantable Electronic Devices
    Status: Unpublished
    Abstract: A major challenge facing the development of implantable devices for clinical use is in finding a suitable power source for such devices. The power source should be able to generate an electric current for extended periods of time. Biofuel cells (BFC) provide some promise in this respect, as their function is primarily based on coupling the oxidation of glucose to the reduction of molecular oxygen to water. Under ideal conditions, the only byproducts of the BFC would simply be carbon dioxide and water. Both glucose and oxygen are present in the cells and tissues of all eukaryotic organisms, including human beings. It might, therefore, be possible to tap into the body's own resources, including the metabolic properties of our cells, to generate enough energy to power an array of clinical devices. The experiments described in this paper serve as a first step toward the goal of designing a BFC that would be based on transducing the power of oxidative metabolism within our own cells into an electrical current. In the first phase of our experiments, the function and current output of a specific type of BFC, called a microbial fuel cell (MFC)is investigated. The behavior and characteristics of such biofuel cells have been well documented in the scientific literature. MFCs essentially convert the biochemical energy of bacteria into electrical energy. A strain of E. Coli is used in our study. In the second phase of our experiments, an attempt is made to derive electrical currents from BFCs employing human white blood cells.
    Date: 09 June 2004
    Date Type: Completion
    Defense Date: 02 April 2004
    Approval Date: 09 June 2004
    Submission Date: 15 April 2004
    Access Restriction: No restriction; Release the ETD for access worldwide immediately.
    Patent pending: No
    Institution: University of Pittsburgh
    Thesis Type: Master's Thesis
    Refereed: Yes
    Degree: MSBeng - Master of Science in Bioengineering
    URN: etd-04152004-161343
    Uncontrolled Keywords: electron mediator; electron transport chain; Escherichia Coli; fuel cell; NADPH oxidase; oxidative metabolism; potassium ferricyanide; proton exchange membrane
    Schools and Programs: Swanson School of Engineering > Bioengineering
    Date Deposited: 10 Nov 2011 14:37
    Last Modified: 04 May 2012 16:02
    Other ID: http://etd.library.pitt.edu/ETD/available/etd-04152004-161343/, etd-04152004-161343

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