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Spontaneous Dyskinesia and Familial Liability to Schizophrenia

Tarbox, Sarah I (2005) Spontaneous Dyskinesia and Familial Liability to Schizophrenia. Master's Thesis, University of Pittsburgh. (Unpublished)

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Several factors suggest that spontaneous dyskinesia may be a useful non-diagnosis phenotype for further elucidating the specific nature of the genetic contribution to schizophrenia. For example, involuntary movement abnormalities have been observed in both medicated and unmedicated schizophrenia patients, in individuals with schizotypal personality disorder, and sometimes in siblings of schizophrenia patients. However, there are many inconsistencies present in the literature to date. The current study thus sought to investigate the existence of spontaneous dyskinesia in schizophrenia patient probands, their non-psychotic siblings, and healthy controls in order to clarify its potential value as an "endophenotypes" in genetic studies of schizophrenia. Videotaped interviews were coded for the presence of spontaneous, involuntary movement abnormalities by a trained and reliable rater who was blind to group and family status. The results of this study indicated that siblings of schizophrenia patients did not display significantly more involuntary movements compared to controls, although tremor was observed in a few siblings. In contrast, schizophrenia patients did display significantly more involuntary movements compared to controls as well as their non-psychotic siblings. The lack of significant differences between siblings and controls argues against a strong association between spontaneous dyskinesia and an underlying genetic liability to schizophrenia. Thus, it appears that involuntary movement abnormalities may be limited in their utility as endophenotypes in genetic studies of schizophrenia, despite being associated with schizophrenia itself.


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Item Type: University of Pittsburgh ETD
Status: Unpublished
CreatorsEmailPitt UsernameORCID
Tarbox, Sarah Isat7@pitt.eduSAT7
ETD Committee:
TitleMemberEmail AddressPitt UsernameORCID
Committee ChairPogue-Geile, Michael Fmfpg@pitt.eduMFPG
Committee MemberCohn, Jeffrey F
Committee MemberFiez, Julie
Committee MemberSchmidt, Karen L
Date: 9 June 2005
Date Type: Completion
Defense Date: 24 January 2005
Approval Date: 9 June 2005
Submission Date: 15 April 2005
Access Restriction: No restriction; Release the ETD for access worldwide immediately.
Institution: University of Pittsburgh
Schools and Programs: Dietrich School of Arts and Sciences > Psychology
Degree: MS - Master of Science
Thesis Type: Master's Thesis
Refereed: Yes
Uncontrolled Keywords: endophenotype; movement; relatives; schizophrenia; siblings; spontaneous dyskinesia
Other ID:, etd-04152005-135304
Date Deposited: 10 Nov 2011 19:37
Last Modified: 15 Nov 2016 13:40


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