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High Resolution Fast MRI and MRSI using Spiral Data Acquisition

Zhu, He (2008) High Resolution Fast MRI and MRSI using Spiral Data Acquisition. Doctoral Dissertation, University of Pittsburgh. (Unpublished)

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In this thesis, spiral k-space sampling was configured differently for two applications in Magnetic Resonance Spectroscopic Imaging (MRSI) and time resolved 3D Magnetic Resonance Imaging (MRI). Selective Multiple Quantum Coherence Transfer (Sel-MQC) technique was implemented in in vivo MRSI in combination with Spiral data acquisition. The Spiral Sel-MQC technique enabled fast mapping of Polyunsaturated Fatty Acids (PUFA) in human breast in vivo compared to Chemical Shift Imaging (CSI). The Sel-MQC technique utilizes a scalar coupling to excite PUFA signal while suppressing other resonances in lipid and water. An in vivo 2D Sel- MQC sequence was first implemented to optimize the performance of the Sel-MQC excitation and to investigate the compositions of PUFA as well as Monounsaturated Fatty Acids (MUFA). Spiral data acquisition was then implemented to image PUFA signal exclusively. An image can be acquired in 1-2 min with 16 or 32 scans. Time resolved 3D MRI was also developed with high spatial and temporal resolutions with spiral data acquisition. Off-resonance correction was performed using inhomogeneity field maps. View sharing and sliding window reconstruction were utilized to generate high temporal resolution. High resolution 3D angiograms were generated at 1-2 seconds per frame in vivo. A quantitative method was developed to evaluate the performance of spiral parameters in these applications. This method approximates spiral imaging as a process of linear estimation. The optimal spiral parameters can be determined by finding the least estimation error. Two in vivo applications of spiral data acquisition discussed in this thesis shows that spiral data acquisition can shorten scan times by a factor of up to 10. It can, therefore, enable clinics to include advanced MR techniques such as Sel-MQC and time resolved 3D MRI to enhance diagnosis of cancer or vascular diseases.


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Item Type: University of Pittsburgh ETD
Status: Unpublished
CreatorsEmailPitt UsernameORCID
Zhu, Hehezst2@pitt.eduHEZST2
ETD Committee:
TitleMemberEmail AddressPitt UsernameORCID
Committee ChairLowe,
Committee CoChairHe,
Committee MemberSnoke, Davidsnoke@pitt.eduSNOKE
Committee MemberMueller, Jamesmueller@pitt.eduMUELLER
Committee MemberRoskies,
Committee MemberWang,
Date: 29 January 2008
Date Type: Completion
Defense Date: 20 November 2006
Approval Date: 29 January 2008
Submission Date: 16 April 2007
Access Restriction: 5 year -- Restrict access to University of Pittsburgh for a period of 5 years.
Institution: University of Pittsburgh
Schools and Programs: Dietrich School of Arts and Sciences > Physics
Degree: PhD - Doctor of Philosophy
Thesis Type: Doctoral Dissertation
Refereed: Yes
Uncontrolled Keywords: magnetic resonance; spectroscopy; fast acquisition; spiral imaging
Other ID:, etd-04162007-140932
Date Deposited: 10 Nov 2011 19:37
Last Modified: 15 Nov 2016 13:40


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