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The Pederin Family: A Synthetic Overview

Kellar, Terry Allen (2006) The Pederin Family: A Synthetic Overview. Master's Thesis, University of Pittsburgh. (Unpublished)

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A comprehensive synthetic review of the pederin family of cytotoxins, including pederin, the mycalamides, and psymberin, is presented. A number of approaches to the synthesis of these molecules is covered, including pederic acid, the tetrahydropyranyl ring of pederin, the trioxadecalin ring of the mycalamides, and psymberin fragments. Coupling strategies for these compounds are also summarized. An overview of biological activity at various positions of mycalamide A, as well as some analogs, is given.


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Item Type: University of Pittsburgh ETD
Status: Unpublished
CreatorsEmailPitt UsernameORCID
Kellar, Terry
ETD Committee:
TitleMemberEmail AddressPitt UsernameORCID
Committee ChairFloreancig, Paulflorean@pitt.eduFLOREAN
Committee MemberBrummond, Kaykbrummon@pitt.eduKBRUMMON
Committee MemberKoide, Kazunorikoide@pitt.eduKOIDE
Date: 29 June 2006
Date Type: Completion
Defense Date: 6 April 2006
Approval Date: 29 June 2006
Submission Date: 18 April 2006
Access Restriction: No restriction; Release the ETD for access worldwide immediately.
Institution: University of Pittsburgh
Schools and Programs: Dietrich School of Arts and Sciences > Chemistry
Degree: MS - Master of Science
Thesis Type: Master's Thesis
Refereed: Yes
Uncontrolled Keywords: antitumor; antiviral; cancer; diastereomeric; enantiomeric; immunosuppressant; total synthesis
Other ID:, etd-04182006-204913
Date Deposited: 10 Nov 2011 19:38
Last Modified: 15 Nov 2016 13:40


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