Kellar, Terry Allen
(2006)
The Pederin Family: A Synthetic Overview.
Master's Thesis, University of Pittsburgh.
(Unpublished)
Abstract
A comprehensive synthetic review of the pederin family of cytotoxins, including pederin, the mycalamides, and psymberin, is presented. A number of approaches to the synthesis of these molecules is covered, including pederic acid, the tetrahydropyranyl ring of pederin, the trioxadecalin ring of the mycalamides, and psymberin fragments. Coupling strategies for these compounds are also summarized. An overview of biological activity at various positions of mycalamide A, as well as some analogs, is given.
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Details
| Item Type: |
University of Pittsburgh ETD
|
| Status: |
Unpublished |
| Creators/Authors: |
|
| ETD Committee: |
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| Date: |
29 June 2006 |
| Date Type: |
Completion |
| Defense Date: |
6 April 2006 |
| Approval Date: |
29 June 2006 |
| Submission Date: |
18 April 2006 |
| Access Restriction: |
No restriction; Release the ETD for access worldwide immediately. |
| Institution: |
University of Pittsburgh |
| Schools and Programs: |
Dietrich School of Arts and Sciences > Chemistry |
| Degree: |
MS - Master of Science |
| Thesis Type: |
Master's Thesis |
| Refereed: |
Yes |
| Uncontrolled Keywords: |
antitumor; antiviral; cancer; diastereomeric; enantiomeric; immunosuppressant; total synthesis |
| Other ID: |
http://etd.library.pitt.edu/ETD/available/etd-04182006-204913/, etd-04182006-204913 |
| Date Deposited: |
10 Nov 2011 19:38 |
| Last Modified: |
15 Nov 2016 13:40 |
| URI: |
http://d-scholarship.pitt.edu/id/eprint/7285 |
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