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Control of Budded Domains in Amphiphilic Bilayer Membranes

Uspal, William Eric (2007) Control of Budded Domains in Amphiphilic Bilayer Membranes. Undergraduate Thesis, University of Pittsburgh. (Unpublished)

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Phase separated domains in multicomponent vesicles form spherical buds to reduce interfacial energy. We study the response of a multicomponent budded vesicle to an imposed shear flow with dissipative particle dynamics. We find that shear can either act to stretch the bud open or separate the bud from the vesicle, depending on bud orientation. We examine the interplay of interfacial tension, bending energy, and shear in determining the behavior of the vesicle, and provide criteria for the design of vesicles for controlled bud release.The neck connecting the budded domain with the bulk vesicle assumes a catenoid shape to minimize bending energy. We model the mechanism for pinch-off of catenoid necks with continuum elastic theory and dissipative particle dynamics. We examine pore nucleation and growth driven by Gaussian energy, by the adhesion energy of an encapsulated particle, and by the line energy of an interface between two amphiphile species, aiming to provide principles for the design of vesicles for biomimetic phagocytosis.


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Item Type: University of Pittsburgh ETD
Status: Unpublished
CreatorsEmailPitt UsernameORCID
Uspal, William
ETD Committee:
TitleMemberEmail AddressPitt UsernameORCID
Committee ChairBalazs, Anna Cbalazs1@engr.pitt.eduBALAZS
Committee MemberLeibovich, Adam Kakl2@pitt.eduAKL2
Committee MemberSingh, Chandralekhaclsingh@pitt.eduCLSINGH
Committee MemberFasolka, Michael
Date: 16 July 2007
Date Type: Completion
Defense Date: 4 April 2007
Approval Date: 16 July 2007
Submission Date: 19 April 2007
Access Restriction: No restriction; Release the ETD for access worldwide immediately.
Institution: University of Pittsburgh
Schools and Programs: Swanson School of Engineering > Engineering Physics
David C. Frederick Honors College
Degree: BS - Bachelor of Science
Thesis Type: Undergraduate Thesis
Refereed: Yes
Uncontrolled Keywords: bilayers; bioenergetics; biomechanics; Biomembranes; biothermics; computer simulations; phase separation; shear flow; surface energy; vesicles
Other ID:, etd-04192007-154131
Date Deposited: 10 Nov 2011 19:39
Last Modified: 15 Nov 2016 13:41


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