Link to the University of Pittsburgh Homepage
Link to the University Library System Homepage Link to the Contact Us Form

Inhibition of thirst when dehydrated rats drink water or saline

Hoffmann, Myriam L. (2006) Inhibition of thirst when dehydrated rats drink water or saline. Master's Thesis, University of Pittsburgh. (Unpublished)

Primary Text

Download (317kB) | Preview


The present experiments sought to identify the physiological signals that inhibit thirst when dehydrated rats drink water or NaCl solution. Rats were deprived of drinking fluid but not food overnight. When allowed to drink again, the dehydrated animals consumed water or saline (0.05 M, 0.10 M, 0.15 M, or 0.20 M NaCl solution) almost continuously for 5-8 min before stopping. The volumes consumed were similar regardless of which fluid they ingested, but blood analyses indicated that increased plasma osmolality and decreased plasma volume, or both, still remained when drinking terminated. These results suggest that the composition of the ingested fluid is less significant than its volume in providing an early signal that inhibits thirst and fluid consumption by dehydrated rats. Analyses of the gastrointestinal tracts revealed that the cumulative volume in the stomach and small intestine correlated highly with the amount consumed regardless of which fluid was ingested. These and other results suggest that the volume of fluid ingested by dehydrated rats is sensed by stretch receptors detecting distension of the stomach and small intestine, which provide an early inhibitory stimulus of thirst.


Social Networking:
Share |


Item Type: University of Pittsburgh ETD
Status: Unpublished
CreatorsEmailPitt UsernameORCID
Hoffmann, Myriam
ETD Committee:
TitleMemberEmail AddressPitt UsernameORCID
Committee ChairStricker, Edward Mstricker@bns.pitt.eduEDSTRICK
Committee MemberSved, Alan Fsved@bns.pitt.eduSVED
Committee MemberRinaman, Linda Mrinaman@bns.pitt.eduRINAMAN
Date: 28 June 2006
Date Type: Completion
Defense Date: 11 April 2006
Approval Date: 28 June 2006
Submission Date: 26 April 2006
Access Restriction: No restriction; Release the ETD for access worldwide immediately.
Institution: University of Pittsburgh
Schools and Programs: Dietrich School of Arts and Sciences > Neuroscience
Degree: MS - Master of Science
Thesis Type: Master's Thesis
Refereed: Yes
Uncontrolled Keywords: dehydration; gastrointestinal distension; visceral osmoreceptors; water deprivation
Other ID:, etd-04262006-141151
Date Deposited: 10 Nov 2011 19:42
Last Modified: 15 Nov 2016 13:42


Monthly Views for the past 3 years

Plum Analytics

Actions (login required)

View Item View Item