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Joint Modeling Of Censored Longitudinal and Event Time Data

Pike, Francis (2011) Joint Modeling Of Censored Longitudinal and Event Time Data. Doctoral Dissertation, University of Pittsburgh. (Unpublished)

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Abstract

Longitudinal censoring is a common artifact when evaluating biomarkers and an obstacle to overcome when jointly investigating the longitudinal nature of the data and the impact on the survival prognoses of a study population. To fully appreciate the complexity of this scenario one has to devise a modeling strategy that can simultaneously account for (i) longitudinal censoring, (ii) outcome dependent dropout, and potentially (iii) correlated biomarkers. In this thesis we propose a novel joint modeling approach to account for the aforementioned issues by linkingtogether a univariate or multivariate Tobit mixed effects model to a suitable parametric event time distribution. This method is significant to public health research since it enables researchers to evaluate the evolution of the disease process in the presence of complex biomarker data where there may be censoring, correlation, and outcome dependent dropout. This approach allows for the analysis of data in a single unified framework. The performance of the proposed Joint Tobit model will be compared to the commonly used "fill-in" methods for censored longitudinal data in a joint modeling framework. Furthermore, we will show that the implementation of our proposed model is fairly straightforward in commercially available software, thus avoiding the complexity and problem specific nature of the expectation maximization (EM) algorithm.


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Details

Item Type: University of Pittsburgh ETD
Status: Unpublished
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Pike, Francisfrp3@pitt.eduFRP3
ETD Committee:
TitleMemberEmail AddressPitt UsernameORCID
Committee ChairWeissfeld, Lisalweis@pitt.eduLWEIS
Committee MemberChang, Joycechangjh@upmc.edu
Committee MemberKong, Lanlkong@pitt.eduLKONG
Committee MemberUnruh, Markunruh@pitt.eduUNRUH
Date: 23 September 2011
Date Type: Completion
Defense Date: 16 June 2011
Approval Date: 23 September 2011
Submission Date: 9 May 2011
Access Restriction: 5 year -- Restrict access to University of Pittsburgh for a period of 5 years.
Institution: University of Pittsburgh
Schools and Programs: Graduate School of Public Health > Biostatistics
Degree: PhD - Doctor of Philosophy
Thesis Type: Doctoral Dissertation
Refereed: Yes
Uncontrolled Keywords: Frailty models; longiitdinal models; Tobit
Other ID: http://etd.library.pitt.edu/ETD/available/etd-05092011-235956/, etd-05092011-235956
Date Deposited: 10 Nov 2011 19:44
Last Modified: 15 Nov 2016 13:43
URI: http://d-scholarship.pitt.edu/id/eprint/7838

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