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Electrically Controlled Release of Dopamine from Nanoporous Conducting Polymers

Freedman, Michael Scott (2010) Electrically Controlled Release of Dopamine from Nanoporous Conducting Polymers. Undergraduate Thesis, University of Pittsburgh. (Unpublished)

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Abstract

Conducting polymers are synthesized on electrode surfaces, conduct electricity, and can incorporate different molecules. These properties make them ideal for biocompatible application to interface with the nervous system, particularly for drug release. This thesis describes the development of system based on nanoporous conducting polymers for the controlled release of dopamine. Polypyrrole, a conducting polymer, was demonstrated to release the neurotransmitter dopamine when electrically stimulated. Dopamine release from nanoporous and non-nanoporous polypyrrole films was characterized. Diffusion from unstimulated polypyrrole accounts for much of the dopamine release, while a fraction of the dopamine was released in a controllable fashion when the polypyrrole film was stimulated. Dopamine was retained by holding the releasing electrode at a negative potential. Dopamine release was quantified by fast-scan cyclic voltammetry using carbon-fiber microelectrodes.Successful controlled release of dopamine from conducting polymer films is promising for treatment of neurological conditions characterized by low dopamine levels, neuroscience research investigating the effects of neurotransmitters on network activity, and it also serves as a model system for controlled release of other similar molecules of pharmaceutical interest.


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Details

Item Type: University of Pittsburgh ETD
Status: Unpublished
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Freedman, Michael Scottmichael.s.freedman@gmail.com
ETD Committee:
TitleMemberEmail AddressPitt UsernameORCID
Committee ChairCui, Xinyan Tracyxic11@pitt.eduXIC11
Committee MemberMichael, Adrianamichael@pitt.eduAMICHAEL
Committee MemberBi, Guoqiangguoqiang.bi@gmail.com
Committee MemberAmemiya, Shigeruamemiya@pitt.eduAMEMIYA
Date: 12 May 2010
Date Type: Completion
Defense Date: 16 March 2010
Approval Date: 12 May 2010
Submission Date: 11 May 2010
Access Restriction: 5 year -- Restrict access to University of Pittsburgh for a period of 5 years.
Institution: University of Pittsburgh
Schools and Programs: Swanson School of Engineering > Bioengineering
University Honors College
Degree: BS - Bachelor of Science
Thesis Type: Undergraduate Thesis
Refereed: Yes
Uncontrolled Keywords: conducting polymer; controlled release; dopamine
Other ID: http://etd.library.pitt.edu/ETD/available/etd-05112010-152535/, etd-05112010-152535
Date Deposited: 10 Nov 2011 19:44
Last Modified: 15 Nov 2016 13:43
URI: http://d-scholarship.pitt.edu/id/eprint/7849

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