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Growth Hormone Genes and Prostate Cancer Risk

Dressen, Amy S (2007) Growth Hormone Genes and Prostate Cancer Risk. Master's Thesis, University of Pittsburgh. (Unpublished)

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Abstract

Background: Growth hormone (GH) SNPs are associated with breast cancer and colon cancer. The author investigated the association of prostate cancer with genetic polymorphisms in GH SNPs in the Ancillary MrOS study. Methods: Included in the current investigation were 128 men with prostate cancer and 743 healthy men, 65 years of age or older. SNPs were tested in Growth Hormone 1 (GH1, n=4), Growth Hormone Receptors (GHR, n=15), Growth Hormone-Releasing Hormone (GHRH, n=4), Growth Hormone-Releasing Hormone Receptors (GHRHR, n=10), Ghrelin (GHRL, n=8), and Growth Hormone Secretagogue Receptor (GHSR, n=9) genes for an association with prostate cancer risk. SNPs were selected based on HapMap Phase 1 and based on functional variation. The SNPs were genotyped using Illumina Assay and were included if the minor allele frequency was 1% or greater. Logistic regression analysis was used to examine associations, adjusted for age, weight, BMI, truncal % fat, total % fat, and diabetes. Similarly, tests of trends and tests of dominant/recessive effect were performed. Results: After adjusting for potential confounding factors, two GH1 SNPs, one GHR SNP, one GHRH SNP, two GHRHR SNPs, one GHRL SNP, and one GHSR SNP showed significant associations with prostate cancer risk. Public Health Significance: If the relationships observed in this study are confirmed, it would justify the investigation of approaches that would reduce the activity of GH in those at high risk for prostate cancer. Conclusions: The results of the current study suggest that GH SNPs are associated with prostate cancer risk. This provides support for replication of these findings in other studies.


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Details

Item Type: University of Pittsburgh ETD
Status: Unpublished
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Dressen, Amy Sasdressen@gmail.com
ETD Committee:
TitleMemberEmail AddressPitt UsernameORCID
Committee ChairWeissfeld, Joeljwepid@pitt.eduJWEPID
Committee MemberBunker, Clarebunkerc@edc.pitt.eduBUNKERC
Committee MemberZmuda, Joezmudaj@edc.pitt.eduEPIDJMZ
Committee MemberConley, Yvetteyconley@pitt.eduYCONLEY
Date: 25 September 2007
Date Type: Completion
Defense Date: 15 June 2007
Approval Date: 25 September 2007
Submission Date: 15 June 2007
Access Restriction: 5 year -- Restrict access to University of Pittsburgh for a period of 5 years.
Institution: University of Pittsburgh
Schools and Programs: Graduate School of Public Health > Epidemiology
Degree: MS - Master of Science
Thesis Type: Master's Thesis
Refereed: Yes
Uncontrolled Keywords: prostate cancer; growth hormones; SNPs
Other ID: http://etd.library.pitt.edu/ETD/available/etd-06152007-144251/, etd-06152007-144251
Date Deposited: 10 Nov 2011 19:47
Last Modified: 15 Nov 2016 13:44
URI: http://d-scholarship.pitt.edu/id/eprint/8112

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