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INTERLEUKIN-6, ITS SUBUNIT gp 130 AND THE POTENTIAL RISK OF PROSTATE CANCER IN A POPULATION OF MEN FROM TOBAGO

Roman, Lalicia N. (2006) INTERLEUKIN-6, ITS SUBUNIT gp 130 AND THE POTENTIAL RISK OF PROSTATE CANCER IN A POPULATION OF MEN FROM TOBAGO. Master's Thesis, University of Pittsburgh. (Unpublished)

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Abstract

Prostate cancer is a public health concern, particularly to the African-American community. African-American men are disproportionately affected and experience prostate cancer rates about 60% more often than white Americans. It is the second leading cancer in men and it is second only to lung cancer in cancer related deaths. This is a significant public health problem. This paper will focus on the gene Interleukin 6 signal transducer isoform 1 (IL6ST), on chromosome 5q11.2, with polymorphisms relating to gp130 [rs 3730293 and rs 3729960]; both single nucleotide polymorphisms result in an amino acid change. The change is Glycine to Arginine for rs 3729960 which is located in exon 14 and Isoleucine to Threonine for rs 3730293 which is located in exon 10. Human IL-6 signaling requires the 80kDa IL-6R receptor, which is responsible for IL-6 specificity and the 130kDa glycoprotein, gp130, the signal transduction subunit for signal transduction to occur. IL-6 acts through its receptors which are polymorphic, and subsequently may cause it to have different functionality. A population based case/control study was conducted to evaluate the influence of gp130 snps on prostate cancer risk in an Afro-Caribbean male population of Tobago. This population was chosen because of the high prevalence of prostate cancer. A subset of 1000 samples taken from a study done by Bunker et al, was genotyped by PCR and fluorescence polarization methods. Statistical analysis yielded all estimated allele frequencies to be in Hardy Weinberg Equilibrium. Chi square analysis of the cases and controls yielded no significant association of the gp130 snps and prostate cancer risk.


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Details

Item Type: University of Pittsburgh ETD
Status: Unpublished
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Roman, Lalicia N.leelee412@hotmail.com, lnr7@pitt.eduLNR7
ETD Committee:
TitleMemberEmail AddressPitt UsernameORCID
Committee ChairBarmada, M. Michaelmichaelbarmada@hgen.pitt.edu
Committee MemberFerrell, Robertrferrell@hgen.pitt.eduRFERRELL
Committee MemberThomas, Stephensbthomas@cmh.pitt.edu
Date: 8 August 2006
Date Type: Completion
Defense Date: 25 April 2006
Approval Date: 8 August 2006
Submission Date: 23 June 2006
Access Restriction: No restriction; Release the ETD for access worldwide immediately.
Institution: University of Pittsburgh
Schools and Programs: Graduate School of Public Health > Human Genetics
Degree: MS - Master of Science
Thesis Type: Master's Thesis
Refereed: Yes
Uncontrolled Keywords: autocrine; cytokine; HHV-8; paracrine
Other ID: http://etd.library.pitt.edu/ETD/available/etd-06232006-175315/, etd-06232006-175315
Date Deposited: 10 Nov 2011 19:48
Last Modified: 15 Nov 2016 13:45
URI: http://d-scholarship.pitt.edu/id/eprint/8177

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