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Do sleep dimensions predict primary and secondary antibody responses to vaccination?

Prather, Aric Andrew (2010) Do sleep dimensions predict primary and secondary antibody responses to vaccination? Doctoral Dissertation, University of Pittsburgh. (Unpublished)

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The immune system may contribute to associations between disturbed sleep and increased disease risk. Until recently, however, much of the work examining immune correlates of sleep employed in vitro measures of immunity of unknown clinical relevance. To address this limitation, we prospectively examined associations of several sleep parameters (sleep duration, efficiency, and quality) with the magnitude of primary and secondary antibody responses to the hepatitis B vaccination series among a community sample of 125 relatively healthy, older adults. Participants completed electronic sleep diaries for 7 consecutive days (3 days prior, the day of, and 3 days following) at each of the 3 hepatitis B injections. In addition, a subset of participants (n=104) wore an actigraph on the 3 days prior and 3 days following the first injection to provide an objective measure of sleep behavior. In regard to primary antibody responses following the first dose of the vaccine, poorer sleep efficiency, greater sleep fragmentation, and greater night to night variability in sleep duration were associated with higher antibody responses; however, these associations were reduced after adjustment for sociodemographic covariates, including age, gender, race, and body mass index (BMI). In contrast, shorter sleep duration, measured via actigraphy alone or averaged across all available nights of sleep assessment, was associated with lower secondary antibody levels, assessed 5-months after the second injection, and a poorer likelihood of being a clinically protected at the conclusion of the vaccination series. Participants with low and high variability in sleep duration also displayed lower secondary antibody levels and decreased likelihood of being clinically protected. These findings remained largely significant after adjustment for sociodemographic covariates. Taken together, these findings provide preliminary evidence for the influence of sleep on primary and secondary antibody responses to the hepatitis B vaccine. Further exploration of the role of poor sleep in susceptibility to infectious illness is warranted.


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Item Type: University of Pittsburgh ETD
Status: Unpublished
CreatorsEmailPitt UsernameORCID
Prather, Aric Andrewaap12@pitt.eduAAP12
ETD Committee:
TitleMemberEmail AddressPitt UsernameORCID
Committee ChairMarsland, Anna Lmarsland@pitt.eduMARSLAND
Committee MemberVotruba-Drzal, Elizabethevotruba@pitt.eduEVOTRUBA
Committee MemberMatthews, Karenmatthewska@upmc.eduXYOO
Committee MemberHall, Marticahallmh@upmc.eduMHH1
Committee MemberKamarck, Thomastkam@pitt.eduTKAM
Date: 30 September 2010
Date Type: Completion
Defense Date: 15 June 2010
Approval Date: 30 September 2010
Submission Date: 5 July 2010
Access Restriction: No restriction; Release the ETD for access worldwide immediately.
Institution: University of Pittsburgh
Schools and Programs: Dietrich School of Arts and Sciences > Psychology
Degree: PhD - Doctor of Philosophy
Thesis Type: Doctoral Dissertation
Refereed: Yes
Uncontrolled Keywords: antibody; infectious illness; sleep; vaccination
Other ID:, etd-07052010-100218
Date Deposited: 10 Nov 2011 19:49
Last Modified: 19 Dec 2016 14:36


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