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Negative Affect and Vasomotor Symptoms in the Daily Hormone Study

Gibson, Carolyn Jo (2011) Negative Affect and Vasomotor Symptoms in the Daily Hormone Study. Master's Thesis, University of Pittsburgh. (Unpublished)

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Purpose: Vasomotor symptoms (VMS) are linked to poorer health and quality of life, and are common in the menopausal transition. Negative affect is consistently associated with self-reported VMS, but interpretation of the temporal and directional nature of this relationship has been limited by potentially biased retrospective recall of VMS. Using prospective data from end-of-day daily diaries, we examined the daily association and the day-to-day temporal relationship between negative affect and VMS. Methods: Data were from the third wave of the Daily Hormone Study (DHS) (n=625). DHS is a substudy of the Study of Women's Health Across the Nation (SWAN), a multi-site community-based prospective cohort study of the menopausal transition. Daily affect and VMS were reported in diaries over 12-50 days. Multilevel mixed models, with daily observations nested within women, were used to determine the associations between daily diary-reported VMS and negative affect, adjusted by woman-level covariates (antidepressant use, age, education, menopausal status, self-reported health, and race/ethnicity) drawn from annual SWAN visits. Results: Overall, VMS was reported on at least one day of observation by 327 women (52.3%). Women with higher average negative affect were more likely to ever report VMS (OR 1.79, 95% CI 1.30-2.45, p<.001). Negative affect was also positively associated with VMS (OR 1.76, 95% CI 1.43-2.17, p<.001) within each 24 hour period. Negative affect, adjusted by same day VMS, was not predictive of next day VMS (OR 1.107, 95% CI .85-1.35, p=.55), while VMS, adjusted by same day negative affect, was predictive of negative affect the next day (OR 1.27, 95% CI 1.03-1.58, p=.01). Conclusions: VMS and negative affect were positively associated with each other using prospective daily diaries. Assessment of temporal relationships suggests that VMS precedes acute elevations in negative affect, but negative affect does not increase likelihood of VMS.


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Item Type: University of Pittsburgh ETD
Status: Unpublished
CreatorsEmailPitt UsernameORCID
Gibson, Carolyn Jocjg40@pitt.eduCJG40
ETD Committee:
TitleMemberEmail AddressPitt UsernameORCID
Committee ChairMatthews, Karenmatthewska@upmc.eduXYOO
Committee MemberBromberger, Joycebrombergerjt@upmc.eduJBROM
Committee MemberThurston, Rebeccathurstonrc@upmc.eduRCT10
Committee MemberKamarck, Thomastkam@pitt.eduTKAM
Date: 14 September 2011
Date Type: Completion
Defense Date: 9 December 2010
Approval Date: 14 September 2011
Submission Date: 27 July 2011
Access Restriction: No restriction; Release the ETD for access worldwide immediately.
Institution: University of Pittsburgh
Schools and Programs: Dietrich School of Arts and Sciences > Psychology
Degree: MS - Master of Science
Thesis Type: Master's Thesis
Refereed: Yes
Uncontrolled Keywords: menopause; negative affect; vasomotor symptoms
Other ID:, etd-07272011-130647
Date Deposited: 10 Nov 2011 19:54
Last Modified: 19 Dec 2016 14:36


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