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Properties and Functions of Ih in Hippocampal Area CA3 Interneurons

Anderson, Warren D (2009) Properties and Functions of Ih in Hippocampal Area CA3 Interneurons. Master's Thesis, University of Pittsburgh. (Unpublished)

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Ih is an important contributor to the subthreshold membrane properties of various mammalian neurons, including interneurons. Here I characterize the properties of Ih in a subpopulation of hippocampal area CA3 interneurons with somata in stratum radiatum and stratum lacunosom moleculare. As shown in previous studies, Ih in these cells has sigmoidal voltage dependence of activation with kinetics characterized by two exponential components for both channel activation and deactivation. Interestingly, the activation and deactivation kinetics were most aptly described by distinct functions of voltage. These results were incorporated into a novel biophysical model of Ih that was applied in single compartment model simulations and dynamic clamp experiments. Finally, I assessed the functional consequences of Ih by examining the effects of this current on subthreshold temporal summation of mossy fiber EPSPs as well as frequency dependent neuronal responses. My results show that Ih decreases temporal summation of mossy fiber EPSPs but does not impart resonance in CA3 interneurons at potentials where Ih is active.


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Item Type: University of Pittsburgh ETD
Status: Unpublished
CreatorsEmailPitt UsernameORCID
Anderson, Warren
ETD Committee:
TitleMemberEmail AddressPitt UsernameORCID
Committee ChairBarrionuevo, Germangerman@pitt.eduGERMAN
Committee MemberJohnson, Jonjjohnson@pitt.eduJJOHNSON
Committee MemberMeriney, Stevemeriney@pitt.eduMERINEY
Date: 29 September 2009
Date Type: Completion
Defense Date: 15 May 2009
Approval Date: 29 September 2009
Submission Date: 28 July 2009
Access Restriction: No restriction; Release the ETD for access worldwide immediately.
Institution: University of Pittsburgh
Schools and Programs: Dietrich School of Arts and Sciences > Neuroscience
Degree: MS - Master of Science
Thesis Type: Master's Thesis
Refereed: Yes
Uncontrolled Keywords: Biophysics; CA3; Computational Modeling; Hippocampus; Ih; Impedance; Interneuron; Oscillations; Resonance; Synaptic Integration; Temporal Summation; Voltage ated Channel
Other ID:, etd-07282009-105110
Date Deposited: 10 Nov 2011 19:54
Last Modified: 15 Nov 2016 13:47


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