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SUBCLINICAL CARDIOVASCULAR DISEASE AND ITS ASSOCIATED RISK FACTORS IN DIFFERENT POPULATION GROUPS

Choo, Jina (2008) SUBCLINICAL CARDIOVASCULAR DISEASE AND ITS ASSOCIATED RISK FACTORS IN DIFFERENT POPULATION GROUPS. Doctoral Dissertation, University of Pittsburgh. (Unpublished)

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Abstract

Examination of the prevalence of subclinical cardiovascular disease (SCD) may help us to delineate future trends of coronary heart disease (CHD) mortality. There are substantial differences in the prevalence of SCD in different population groups. Identification of explaining factors for the difference in SCD rates across different population groups can provide new preventive strategies for reducing CHD morbidity or mortality. Based on this, the EBCT and Risk Factor Assessment among Japanese and U.S. Men in the Post World War II Birth Cohort (ERA-JUMP) Study is an ongoing population-based-cross-sectional study to examine differences in SCD rates across Japanese, Japanese American, and U.S. white men, and Korean men aged 40-49 years. As a part of the ERA-JUMP study, the present study demonstrated that: 1) among middle-aged men, Koreans in South Korea had a significantly higher level of carotid intima-media thickness than the Japanese in Japan. Middle-aged Korean men may continue to be at more increased risk for CHD than Japanese men at least over the near future. 2) Of polyunsaturated fatty acids, the proportion of linoleic acid was significantly and inversely associated with unfavorable levels of lipoprotein subclasses in three population groups of Japanese, Japanese American, and white men; an inverse association of docoxahexaenoic acid occurred only in white men. 3) Associations between pulse wave velocity (PWV) and cardiovascular risk factors were segmental-specific among white men. Brachial-ankle PWV had a mixed characteristic of stiffness of the central and peripheral arteries, compared to carotid-femoral PWV having a characteristic of the central arteries.Public health importance of these findings is that: First, we can provide scientific information imperative to addressing a health-related problem (i.e., increasing risk for cardiovascular disease in South Korea). Second, the promotion of enriched intakes of linoleic acid (e.g., sunflower, corn, safflower oils) and fish-derived n-3 fatty acids (e.g., mackerel or salmon) should be addressed to public in habitual diet in the prevention of CHD by establishing practical guidelines. Finally, incorporation of both measures of brachial-ankle PWV and carotid-femoral PWV into the assessment of arterial stiffness should be considered when screening a high-risk group for cardiovascular disease.


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Details

Item Type: University of Pittsburgh ETD
Status: Unpublished
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Choo, Jinajinachoo@gmail.com
ETD Committee:
TitleMemberEmail AddressPitt UsernameORCID
Committee ChairSekikawa, Akiraakira@pitt.eduAKIRA
Committee MemberChang, Chung-Chou Hochangjh@upmc.edu
Committee MemberEdmundowicz, DanielEdmuD@upmc.edu
Committee MemberSutton-Tyrrell, Kimtyrrell@edc.pitt.edu
Committee MemberEvans, Rhobert WEvansR@edc.pitt.eduRWE2
Date: 28 September 2008
Date Type: Completion
Defense Date: 25 July 2008
Approval Date: 28 September 2008
Submission Date: 30 July 2008
Access Restriction: 5 year -- Restrict access to University of Pittsburgh for a period of 5 years.
Institution: University of Pittsburgh
Schools and Programs: Graduate School of Public Health > Epidemiology
Degree: DrPH - Doctor of Public Health
Thesis Type: Doctoral Dissertation
Refereed: Yes
Uncontrolled Keywords: arterial stiffness; atherosclerosis; cardiovascular disease; carotid artery; fatty acids; lipoprotein; population groups
Other ID: http://etd.library.pitt.edu/ETD/available/etd-07302008-144746/, etd-07302008-144746
Date Deposited: 10 Nov 2011 19:55
Last Modified: 15 Nov 2016 13:47
URI: http://d-scholarship.pitt.edu/id/eprint/8740

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