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Neurturin's Role in Sensory Neuron Plasticity

Wang, Ting (2011) Neurturin's Role in Sensory Neuron Plasticity. Doctoral Dissertation, University of Pittsburgh. (Unpublished)

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Primary sensory neurons are one of the major components of the peripheral nervous system and are required for collecting and transmitting information regarding the external and internal environment to the central nervous system (CNS). The cell bodies of these neurons are located in peripheral ganglia adjacent to the spinal cord and associated with cranial nerves V, VII, IX and X (cranial nerves I, II, VIII also carry sensory information but have specialized sensory organs that detect specific stimuli). Primary sensory neurons whose cells bodies are found in spinal ganglia (also called dorsal root ganglia (DRG)) have been the focus of intense scientific investigation because of their role in transmitting sensation including those associated with pain and as a model system for understanding mechanisms of development and plasticity. The studies presented in this dissertation focus on the interactions between primary sensory neurons and growth factors that regulate developmental events, as well as adult physiology. In particular, these studies examine sensory neurons that respond to the growth factor neurturin (NRTN), the majority of which innervate the epidermis.


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Item Type: University of Pittsburgh ETD
Status: Unpublished
CreatorsEmailPitt UsernameORCID
Wang, Tingtiw12@pitt.eduTIW12
ETD Committee:
TitleMemberEmail AddressPitt UsernameORCID
Committee ChairAlbers, Kathryn Mkaa2@pitt.eduKAA2
Committee MemberDavis, Brian Mbmd1@pitt.eduBMD1
Committee MemberHingtgen, Cynthia
Committee MemberGebhart, Gerald
Committee MemberRinaman, Lindarinaman@pitt.eduRINAMAN
Committee MemberKoerber, Richardrkoerber@pitt.eduRKOERBER
Date: 10 August 2011
Date Type: Completion
Defense Date: 1 March 2011
Approval Date: 10 August 2011
Submission Date: 4 August 2011
Access Restriction: No restriction; Release the ETD for access worldwide immediately.
Institution: University of Pittsburgh
Schools and Programs: School of Medicine > Neurobiology
Degree: PhD - Doctor of Philosophy
Thesis Type: Doctoral Dissertation
Refereed: Yes
Uncontrolled Keywords: GFRalpha1; GFRalpha2; TRPM8; GFRalpha3 Runx1
Other ID:, etd-08042011-111349
Date Deposited: 10 Nov 2011 19:57
Last Modified: 15 Nov 2016 13:48


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