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Gastric Emptying and Intestinal Absorption of Ingested Water and Saline by Hypovolemic Rats

Bykowski, Michael Ryan (2007) Gastric Emptying and Intestinal Absorption of Ingested Water and Saline by Hypovolemic Rats. Master's Thesis, University of Pittsburgh. (Unpublished)

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Detection of blood volume deficits alters a rat's motivational state by stimulating thirst and salt appetite. In consequence, PEG-treated rats with established hypovolemia adaptively drink both water and hypertonic NaCl solution; indeed, they quickly alternate between drinking both fluids and concoct a mixture isotonic to body fluids - a concentration that is most effective in repairing plasma volume deficits without perturbing pOsm. However, their plasma volume deficits cannot be restored until ingested fluid is absorbed from the GI tract. The present experiment sought to address the issue of whether ingested water accelerates ingestion, gastric emptying, and small intestinal absorption of 0.30 M NaCl. In fact, ingestion of both water and 0.30 M NaCl did accelerate fluid delivery into the systemic circulation. Moreover, as a consequence of fluid leaving the GI tract more quickly, GI distension signals associated with inhibition of fluid intake are quickly removed, leading to larger fluid intakes. The unique behavior of PEG-treated rats corresponds to restoration of their body fluid deficits, including behavioral, physiological, and hormonal aspects of body fluid homeostasis. Clearly, co-existence of thirst and salt appetite is an adaptive behavioral response to hypovolemia.


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Item Type: University of Pittsburgh ETD
Status: Unpublished
CreatorsEmailPitt UsernameORCID
Bykowski, Michael Ryanmrb16@pitt.eduMRB16
ETD Committee:
TitleMemberEmail AddressPitt UsernameORCID
Committee ChairStricker, Edward Mstricker@bns.pitt.eduEDSTRICK
Committee MemberSved, Alansved@bns.pitt.eduSVED
Committee MemberRinaman, Lindarinaman@bns.pitt.eduRINAMAN
Date: 19 September 2007
Date Type: Completion
Defense Date: 6 August 2007
Approval Date: 19 September 2007
Submission Date: 8 August 2007
Access Restriction: 5 year -- Restrict access to University of Pittsburgh for a period of 5 years.
Institution: University of Pittsburgh
Schools and Programs: Dietrich School of Arts and Sciences > Neuroscience
Degree: MS - Master of Science
Thesis Type: Master's Thesis
Refereed: Yes
Uncontrolled Keywords: absorption; gastric emptying; hypovolemia; polyethylene glycol; rats; small intestine
Other ID:, etd-08082007-131950
Date Deposited: 10 Nov 2011 19:58
Last Modified: 15 Nov 2016 13:48


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