Bykowski, Michael Ryan
(2007)
Gastric Emptying and Intestinal Absorption of Ingested Water and Saline by Hypovolemic Rats.
Master's Thesis, University of Pittsburgh.
(Unpublished)
Abstract
Detection of blood volume deficits alters a rat's motivational state by stimulating thirst and salt appetite. In consequence, PEG-treated rats with established hypovolemia adaptively drink both water and hypertonic NaCl solution; indeed, they quickly alternate between drinking both fluids and concoct a mixture isotonic to body fluids - a concentration that is most effective in repairing plasma volume deficits without perturbing pOsm. However, their plasma volume deficits cannot be restored until ingested fluid is absorbed from the GI tract. The present experiment sought to address the issue of whether ingested water accelerates ingestion, gastric emptying, and small intestinal absorption of 0.30 M NaCl. In fact, ingestion of both water and 0.30 M NaCl did accelerate fluid delivery into the systemic circulation. Moreover, as a consequence of fluid leaving the GI tract more quickly, GI distension signals associated with inhibition of fluid intake are quickly removed, leading to larger fluid intakes. The unique behavior of PEG-treated rats corresponds to restoration of their body fluid deficits, including behavioral, physiological, and hormonal aspects of body fluid homeostasis. Clearly, co-existence of thirst and salt appetite is an adaptive behavioral response to hypovolemia.
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Details
| Item Type: |
University of Pittsburgh ETD
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| Status: |
Unpublished |
| Creators/Authors: |
| Creators | Email | Pitt Username | ORCID  |
|---|
| Bykowski, Michael Ryan | mrb16@pitt.edu | MRB16 | |
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| ETD Committee: |
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| Date: |
19 September 2007 |
| Date Type: |
Completion |
| Defense Date: |
6 August 2007 |
| Approval Date: |
19 September 2007 |
| Submission Date: |
8 August 2007 |
| Access Restriction: |
5 year -- Restrict access to University of Pittsburgh for a period of 5 years. |
| Institution: |
University of Pittsburgh |
| Schools and Programs: |
Dietrich School of Arts and Sciences > Neuroscience |
| Degree: |
MS - Master of Science |
| Thesis Type: |
Master's Thesis |
| Refereed: |
Yes |
| Uncontrolled Keywords: |
absorption; gastric emptying; hypovolemia; polyethylene glycol; rats; small intestine |
| Other ID: |
http://etd.library.pitt.edu/ETD/available/etd-08082007-131950/, etd-08082007-131950 |
| Date Deposited: |
10 Nov 2011 19:58 |
| Last Modified: |
15 Nov 2016 13:48 |
| URI: |
http://d-scholarship.pitt.edu/id/eprint/8990 |
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