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Genotypic variations and frequencies of OPRM1 by race/ethnicity group in an orthopedic trauma population

Gowda, Indira (2009) Genotypic variations and frequencies of OPRM1 by race/ethnicity group in an orthopedic trauma population. Undergraduate Thesis, University of Pittsburgh. (Unpublished)

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Abstract

Specific Aims: The complex nature of pain, composed of both subjective and objective components, makes its proper and effective management difficult for every patient. In many instances factors such as race/ethnicity, which affect culture distort the objective nature of self-reported pain levels. Management is further compounded by opioid analgesics, which exert a range of adverse affects that vary in presentation and intensity between individuals. Therefore research in genetics, particularly the OPRM1 gene, may expose more reliable and successful methods for individual pain management. This study sought to accomplish this goal by evaluating the following specific aims: 1) Describe the distributions of genotypes and alleles for the variants, A118G and C17T, 2) Evaluate the distributions of the genotypes for A118G and C17T between races/ethnicities, 3) Evaluate the distribution of self-reported pain scores by genotype, and 4) Evaluate the distribution of opioid use by genotype.Methods: Eighty-three subjects were recruited from Presbyterian Hospital, University of Pittsburgh Medical Center. Variables such as race/ethnicity, pain report, and opioid use were collected from patient report or from the medical record. Genotypes were determined through DNA extraction from saliva samples. Results: The proportions of C17T variant genotypes, CT and TT, were significantly higher in the African-American group as compared to the Caucasian group (p<.001). The pain scores at 15 minutes post-operatively were significantly lower in participants with either the CT and TT genotypes than participants having the CC genotype (p=.039). No significant differences between the genotypes, A118G and C17T, were found for other categories of race/ethnicity, self-reported pain levels, or amount of opioid useConclusions: The finding of higher proportions of the variant CT and TT genotypes in African-American patients relative to Caucasian patients is consistent with the literature. The findings of lower pain scores within the immediate post-operative time frame for those with CT and TT genotypes has not been as well documented in the literature and may support the need for further research in this area. Therefore this study does not support a change in practice for pain management, but it does provide the basis for further research into the SNPs of OPRM1, particularly C17T.


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Details

Item Type: University of Pittsburgh ETD
Status: Unpublished
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Gowda, Indiraimg4@pitt.eduIMG4
ETD Committee:
TitleMemberEmail AddressPitt UsernameORCID
Committee ChairHenker, Richardrhe001@pitt.eduRHE001
Committee MemberDunwoody, Colleendunwoodycj@upmc.edu
Committee MemberSereika, Susan Mssereika@pitt.eduSSEREIKA
Committee MemberConley, Yvetteyconley@pitt.eduYCONLEY
Date: 21 August 2009
Date Type: Completion
Defense Date: 21 July 2009
Approval Date: 21 August 2009
Submission Date: 14 August 2009
Access Restriction: No restriction; Release the ETD for access worldwide immediately.
Institution: University of Pittsburgh
Schools and Programs: School of Nursing > Nursing
University Honors College
Degree: BSN - Bachelor of Science in Nursing
Thesis Type: Undergraduate Thesis
Refereed: Yes
Uncontrolled Keywords: ethnicity; genotypes; mu opioid receptor; opioids; pain; race
Other ID: http://etd.library.pitt.edu/ETD/available/etd-08142009-152411/, etd-08142009-152411
Date Deposited: 10 Nov 2011 19:59
Last Modified: 15 Nov 2016 13:49
URI: http://d-scholarship.pitt.edu/id/eprint/9099

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