Link to the University of Pittsburgh Homepage
Link to the University Library System Homepage Link to the Contact Us Form

The Nature of Schizotypy among Multigenerational Multiplex Schizophrenia Families

Tarbox, Sarah Irene (2010) The Nature of Schizotypy among Multigenerational Multiplex Schizophrenia Families. Doctoral Dissertation, University of Pittsburgh. (Unpublished)

Primary Text

Download (763kB) | Preview


Identification of endophenotypes (I. I. Gottesman & Gould, 2003; I. I. Gottesman & Shields, 1972)] that correlate with familial liability to schizophrenia and are maximally sensitive to a homogeneous subset of risk genes is an important strategy for detecting genes that affect schizophrenia risk. Symptoms of schizotypy may correlate with familial liability to schizophrenia; however, there are critical limitations of the current literature concerning this association. The present study examined the genetic architecture and genetic association between schizotypy and genetic liability to schizophrenia among multigenerational, multiplex schizophrenia families. Genetic schizotypy factors were identified that significantly correlated with genetic liability to schizophrenia, although some relations were unexpected in direction. These genetic factors did not correlate with genetic liability to major depressive disorder or substance dependence. Results suggest that genetic schizotypy factors may have the potential to be particularly useful endophenotypes in genetic linkage analyses of schizophrenia.


Social Networking:
Share |


Item Type: University of Pittsburgh ETD
Status: Unpublished
CreatorsEmailPitt UsernameORCID
Tarbox, Sarah Irenesat7@pitt.eduSAT7
ETD Committee:
TitleMemberEmail AddressPitt UsernameORCID
Committee ChairPogue-Geile, Michael Fmfpg@pitt.eduMFPG
Committee MemberShaw, Danielcasey@pitt.eduCASEY
Committee MemberCheong, JeeWonjcheong@pitt.eduJCHEONG
Committee MemberAlmasy,
Committee MemberNimgaonkar, Vishwajitvishwajitnl@upmc.eduNIMGA
Date: 1 October 2010
Date Type: Completion
Defense Date: 8 September 2009
Approval Date: 1 October 2010
Submission Date: 18 August 2010
Access Restriction: 5 year -- Restrict access to University of Pittsburgh for a period of 5 years.
Institution: University of Pittsburgh
Schools and Programs: Dietrich School of Arts and Sciences > Psychology
Degree: PhD - Doctor of Philosophy
Thesis Type: Doctoral Dissertation
Refereed: Yes
Uncontrolled Keywords: genetic factor analysis; phenotype; relatives; schizotypal personality disorder; social functioning
Other ID:, etd-08182010-005710
Date Deposited: 10 Nov 2011 20:00
Last Modified: 19 Dec 2016 14:37


Monthly Views for the past 3 years

Plum Analytics

Actions (login required)

View Item View Item