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Imaging the role of the caudate nucleus in feedback processing during a declarative memory task

Tricomi Shiflett, Elizabeth (2007) Imaging the role of the caudate nucleus in feedback processing during a declarative memory task. Doctoral Dissertation, University of Pittsburgh. (Unpublished)

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Although the caudate nuclei are involved in processing performance feedback, the specific conditions under which feedback engages the caudate are not well understood. It is unclear whether feedback in a declarative memory task can activate the caudate to the same extent as a non-declarative task. Likewise, it is not known how the type and amount of information carried by feedback affect caudate activation. To answer these questions, I examined brain activation during a feedback-based paired associate word learning task over three rounds of trials with two response options (Experiment 1) and over one round of trials with either two or four response options (Experiment 2). The caudate nuclei were strongly engaged in Experiment 1 only during the second two rounds, when feedback reflected the accuracy of memory. In Experiment 2, differential responses to positive and negative feedback were observed in the caudate nuclei in the 4-choice condition, for which positive feedback provides more information than negative feedback. Responses to positive and negative feedback were not differential in the 2-choice condition and were similar in magnitude to the response elicited by positive feedback in the 4-choice condition. These results indicate that the caudate can be involved in feedback processing during tasks engaging declarative memory, but that activation during such tasks is context dependent. The caudate is most strongly engaged when positive and negative feedback have differential value to the individual. Though not required for learning to occur, caudate activation may nevertheless contribute to feedback-based declarative memory formation.


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Item Type: University of Pittsburgh ETD
Status: Unpublished
CreatorsEmailPitt UsernameORCID
Tricomi Shiflett, Elizabethelt6@pitt.eduELT6
ETD Committee:
TitleMemberEmail AddressPitt UsernameORCID
Committee ChairFiez, Juliefiez@pitt.eduFIEZ
Committee MemberPerfetti, Charlesperfetti@pitt.eduPERFETTI
Committee Member Reichle, Erikreichle@pitt.eduREICHLE
Committee MemberMcClelland,
Committee MemberWheeler, Markwheelerm@pitt.eduWHEELERM
Date: 30 January 2007
Date Type: Completion
Defense Date: 6 September 2006
Approval Date: 30 January 2007
Submission Date: 13 October 2006
Access Restriction: No restriction; Release the ETD for access worldwide immediately.
Institution: University of Pittsburgh
Schools and Programs: Dietrich School of Arts and Sciences > Psychology
Degree: PhD - Doctor of Philosophy
Thesis Type: Doctoral Dissertation
Refereed: Yes
Uncontrolled Keywords: fMRI; learning; memory; reward; caudate; feedback
Other ID:, etd-10132006-105026
Date Deposited: 10 Nov 2011 20:02
Last Modified: 15 Nov 2016 13:50


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