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Use of Simultaneous Inference Under Order Restriction, Stepdown Testing Procedure and Stage-wise Sequential Optimal Design in Clinical Dose Study

Jia, Gang (2005) Use of Simultaneous Inference Under Order Restriction, Stepdown Testing Procedure and Stage-wise Sequential Optimal Design in Clinical Dose Study. Doctoral Dissertation, University of Pittsburgh. (Unpublished)

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This dissertation discusses the design approaches of adaptive dose escalation study and the analysis methods of dose study data, and the relationship between the study design approach and data analysis methods.A general max-min approach to construct simultaneous confidence Intervals for the monotone means of correlated and normally istributed random samples is proposed to analyze correlated dose response data. The approach provides an accurate, flexible and computationally easy way to obtain critical values of simultaneous confidence intervals under monotone order restriction.Stepdown testing procedure for analyzing dose study data is examined and an modified stepdown testing approach is proposed to incorporate the adaptive sampling nature of the study data. An approximate mixture normal distribution of the dose response is proposed to analyze the binary outcome with small sample size at the first stage of the adaptive design.Finally, an optimal stage-wise adptive clinical dose study design is proposed to be applied in dose escalation study with binary outcome and correlated dose response. The study design criteria is defined as a weighted average power to identify all effective dose levels. A back induction algorithm is used to obtain the design parameters. The values of optimal design parameters vary when different analysis methods are used to analyze the study data.Simulation studies are performed to illustrate the two proposed analysis methods and the proposed optimal design approach.


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Item Type: University of Pittsburgh ETD
Status: Unpublished
CreatorsEmailPitt UsernameORCID
ETD Committee:
TitleMemberEmail AddressPitt UsernameORCID
Committee ChairGleser, Leon Jljg@stat.pitt.eduGLESER
Committee MemberSampson, Allan Rasampson@stat.pitt.eduASAMPSON
Committee MemberWieand, Harry
Committee MemberBlock, Henry Whwb@stat.pitt.eduHWB
Date: 31 January 2005
Date Type: Completion
Defense Date: 3 December 2004
Approval Date: 31 January 2005
Submission Date: 28 October 2004
Access Restriction: No restriction; Release the ETD for access worldwide immediately.
Institution: University of Pittsburgh
Schools and Programs: Dietrich School of Arts and Sciences > Statistics
Degree: PhD - Doctor of Philosophy
Thesis Type: Doctoral Dissertation
Refereed: Yes
Uncontrolled Keywords: dose escalation; futility test; correlated dose response; interim analysis
Other ID:, etd-10282004-142719
Date Deposited: 10 Nov 2011 20:03
Last Modified: 15 Nov 2016 13:50


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