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System Identification of Wrist Stiffness in Parkinson's Disease Patients

Sprague, Chris (2008) System Identification of Wrist Stiffness in Parkinson's Disease Patients. Master's Thesis, University of Pittsburgh. (Unpublished)

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The purpose of this work is to investigate the characteristics of motor control systems in Parkinson's disease patients. ARMAX system identification was performed to identify the intrinsic and reflexive, the non-controllable and controllable, components of wrist stiffness, enabling a better understanding of the problems associated with Parkinson's disease. The results show that the intrinsic stiffness dynamics represent the vast majority of the total stiffness in the wrist joint and that the reflexive stiffness dynamics are attributable to a tremor commonly found in Parkinson's disease patients. It was found that Parkinsonian rigidity, a symptom of Parkinson's disease, interferes with the known and traditional methods for separating intrinsic and reflexive components. Resolving this problem could lead to early detection of Parkinson's disease in patients not exhibiting typical symptoms, analytical measurement of the severity of the disease, and as a testing mechanism for the effectiveness of new medicines.


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Item Type: University of Pittsburgh ETD
Status: Unpublished
CreatorsEmailPitt UsernameORCID
Sprague, Chriscps5@pitt.eduCPS5
ETD Committee:
TitleMemberEmail AddressPitt UsernameORCID
Committee ChairMao, Zhi-Hongmaozh@engr.pitt.eduZHM4
Committee MemberLee,
Committee MemberBoston, J. Robertboston@ee.pitt.eduBBN
Date: 30 January 2008
Date Type: Completion
Defense Date: 19 November 2007
Approval Date: 30 January 2008
Submission Date: 6 November 2007
Access Restriction: No restriction; Release the ETD for access worldwide immediately.
Institution: University of Pittsburgh
Schools and Programs: Swanson School of Engineering > Electrical Engineering
Degree: MSEE - Master of Science in Electrical Engineering
Thesis Type: Master's Thesis
Refereed: Yes
Uncontrolled Keywords: Parkinson's Disease; System Identification; Wrist Stiffness
Other ID:, etd-11062007-200215
Date Deposited: 10 Nov 2011 20:04
Last Modified: 15 Nov 2016 13:51


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