Hildebrand, Daniel Kenneth
(2004)
DESIGN AND EVALUATION OF A NOVEL PULSATILE BIOREACTOR FOR BIOLOGICALLY ACTIVE HEART VALVES.
Master's Thesis, University of Pittsburgh.
(Unpublished)
Abstract
Biologically active replacement heart valves (tissue engineered, recellularized xenograft) offer enhanced function compared to current valve therapies by possessing the capacity for remodeling and growth to meet the hemodynamic needs of the patient and eliminating the need for chronic medication. However, many fundamental questions remain as to how these valves will function in vivo, and new in vitro tools need to be created to address these questions. Traditional in vitro heart valve testing devices (mock flow loops) are designed to subject valves to physiologic and pathologic hemodynamic conditions. These devices offer a heart valve designer a useful tool with which to evaluate the mechanical functioning of their device in a variety of well-controlled hemodynamic situations. Unfortunately, these devices have not been designed for testing valves built of biologically active materials which require proper nutrient and waste exchange, pH, temperature, and freedom from attacks by microbial organisms in order to function. Pulsatile bioreactors have been developed to provide the aforementioned biological requirements to developing tissue engineered valves [1, 2], but these systems offer very limited hemodynamic control in comparison to mock flow loops. Therefore, in order to better understand the role of hemodynamics in the function of biologically active heart valves (BAHV), and to thereby create better BAHV designs, a new type of pulsatile bioreactor should be created that also incorporates more of the hemodynamic control found in mock circulatory loops. This thesis details the both the development of such a device and evaluating its functionality.
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Details
| Item Type: |
University of Pittsburgh ETD
|
| Status: |
Unpublished |
| Creators/Authors: |
| Creators | Email | Pitt Username | ORCID  |
|---|
| Hildebrand, Daniel Kenneth | dkhst8@pitt.edu | DKHST8 | |
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| ETD Committee: |
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| Date: |
2 February 2004 |
| Date Type: |
Completion |
| Defense Date: |
2 December 2003 |
| Approval Date: |
2 February 2004 |
| Submission Date: |
21 November 2003 |
| Access Restriction: |
No restriction; Release the ETD for access worldwide immediately. |
| Institution: |
University of Pittsburgh |
| Schools and Programs: |
Swanson School of Engineering > Bioengineering |
| Degree: |
MSBeng - Master of Science in Bioengineering |
| Thesis Type: |
Master's Thesis |
| Refereed: |
Yes |
| Uncontrolled Keywords: |
cardiovascular; heart valve; mock flow loop; pulse duplicator; tissue engineering; windkessel |
| Other ID: |
http://etd.library.pitt.edu/ETD/available/etd-11212003-171437/, etd-11212003-171437 |
| Date Deposited: |
10 Nov 2011 20:05 |
| Last Modified: |
15 Nov 2016 13:51 |
| URI: |
http://d-scholarship.pitt.edu/id/eprint/9744 |
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