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Dai, Weiying (2007) ADVANCEMENTS IN QUANTITATIVE PERFUSION MAGNETIC RESONANCE IMAGING (MRI) OF DEMENTIA. Doctoral Dissertation, University of Pittsburgh. (Unpublished)

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Alzheimer's disease (AD) affects a considerable, and increasing, part of the population. Early diagnosis of AD is very important to permit effective therapy, and minimize AD's social and economic burden. The goal of our research is to evaluate the changes of cerebral perfusion (i.e., blood flow) in the early stages of AD and the effects from hypertension.We studied volunteers with Mild Cognitive Impairment (MCI) and early AD from the Pittsburgh cohort of the Cardiovascular Health Study (CHS) Cognitive Study during a four-year follow-up. Previously, studies used referral patients who typically have more advanced AD. No perfusion data concerning the early and transitional disease stages are currently available from population studies (i.e., subjects who have been monitored longitudinally in time). There are no common techniques for perfusion quantification and image analysis so that inconsistencies are observed between/within studies, modalities, and researchers. Several advancements were achieved in preparation for the cohort study. First, we improved the accuracy and speed of brain perfusion quantification. Second, we improved the accuracy of image registration to a reference brain using quantitative validation of a registration method and performance comparison with a popular registration method. Third, we improved the method of statistical analysis for evaluating the changes of perfusion between groups. Fourth, we evaluated the changes of cerebral perfusion between cognitive groups (controls, MCIs, ADs), and hypertension and normo-tensive subgroups.Individual perfusion maps were improved by measuring and incorporating individual arrival time, saturation effects, and individual inversion efficiency. A fully deformable registration technique was shown to be more accurate than standard techniques like statistical parametric mapping to detect local perfusion changes. All of the published literature for perfusion up-to-date reported decreased perfusion in AD, but we found hyperperfusion in some regions. The regional findings imply that a hemodynamic process, at the capillary level, accompanied the neurodegenerative process. Hypertensive normal cognitive controls demonstrated hypoperfusion in regions usually involved in AD pathology. However, the effect of hypertension was attenuated after the onset of the pathological cognitive process.


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Item Type: University of Pittsburgh ETD
Status: Unpublished
CreatorsEmailPitt UsernameORCID
ETD Committee:
TitleMemberEmail AddressPitt UsernameORCID
Committee ChairChang, Shi-kuochang@cs.pitt.eduSCHANG
Committee MemberAhmed,
Committee MemberGach, H.
Committee MemberUthaisombut,
Date: 30 January 2007
Date Type: Completion
Defense Date: 1 November 2006
Approval Date: 30 January 2007
Submission Date: 1 December 2006
Access Restriction: 5 year -- Restrict access to University of Pittsburgh for a period of 5 years.
Institution: University of Pittsburgh
Schools and Programs: Dietrich School of Arts and Sciences > Computer Science
Degree: PhD - Doctor of Philosophy
Thesis Type: Doctoral Dissertation
Refereed: Yes
Uncontrolled Keywords: brain perfusion; computer vision; magnetic resonance imaging; medical image processing
Other ID:, etd-12012006-130940
Date Deposited: 10 Nov 2011 20:07
Last Modified: 15 Nov 2016 13:52


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