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Mechanisms of dopaminergic neurotoxin-induced blood-brain barrier disruption

Larsen, Niccole Jewel (2008) Mechanisms of dopaminergic neurotoxin-induced blood-brain barrier disruption. Doctoral Dissertation, University of Pittsburgh. (Unpublished)

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Blood-brain barrier disruption in Parkinson's disease and Parkinson's disease models that involve dopaminergic neurodegeneration has been minimally evaluated despite mounting evidence for its involvement. Oxidative stress and neuroinflammation are both involved in Parkinson's disease pathology and also both contribute to blood-brain barrier dysfunction, creating the likelihood that blood-brain barrier disruption is also a pathological feature of the disease. Disruption of the blood-brain barrier can lead to an increased susceptibility to neuronal injury and potentially neurodegeneration due to the invasion of peripheral factors such as immunoglobulins and environmental toxins into the brain. An understanding of mechanisms by which blood-brain barrier disruption occurs may lead to the development of new approaches for the treatment of neurologic diseases such as Parkinson's disease.


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Item Type: University of Pittsburgh ETD
Status: Unpublished
CreatorsEmailPitt UsernameORCID
Larsen, Niccole
ETD Committee:
TitleMemberEmail AddressPitt UsernameORCID
Committee ChairHastings, Teresa Ghastingst@upmc.eduTHASTING
Committee MemberYamamoto, Bryan
Committee MemberDeFranco, Donald Bdod1@pitt.eduDOD1
Committee MemberCard, J. Patrickcard@pitt.eduCARD
Committee MemberGreenamyre, J. Timothyjgreena@pitt.eduJGREENA
Committee MemberPerez, Ruth
Date: 25 January 2008
Date Type: Completion
Defense Date: 6 December 2007
Approval Date: 25 January 2008
Submission Date: 2 December 2007
Access Restriction: 5 year -- Restrict access to University of Pittsburgh for a period of 5 years.
Institution: University of Pittsburgh
Schools and Programs: Dietrich School of Arts and Sciences > Neuroscience
Degree: PhD - Doctor of Philosophy
Thesis Type: Doctoral Dissertation
Refereed: Yes
Uncontrolled Keywords: dopamine; neurodegenerative disease; neuroinflammation; oxidative stress; Parkinson's disease
Other ID:, etd-12022007-112205
Date Deposited: 10 Nov 2011 20:07
Last Modified: 19 Dec 2016 14:37


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