Clausen, Dane J
(2012)
An Investigation in Oxidative Cation Formation: The Total Synthesis of Lactodehydrothyrsiferol and Synthetic Application for a Bimolecular Carbon–Carbon Bond Forming Reaction.
Doctoral Dissertation, University of Pittsburgh.
(Unpublished)
Abstract
The first total synthesis of lactodehydrothyrsiferol, a selective inhibitor of protein phosphatase 2A, was accomplished through the application of our electron-transfer-initiated cyclization reaction. Other highlights of our synthetic strategy include a novel method for the formation of 1,1-disubstuted vinyl iodides from a terminal alkyne, a Suzuki-Miyaura cross coupling reaction on a iodinated allylic carbonate, a one pot diepoxidation of a diene to generate two epoxides with opposite stereochemical identities, an asymmetric Nozaki-Hiyama-Kishi reaction, and the selective deoxygenation of a triol. This document will focus on the key epoxide cascade and completion of the synthesis.
An oxidative method to form Carbon–Carbon bonds through Carbon–Hydrogen bond cleavage is described herein. Chromene and isochromene both form aromatically stabilized oxocarbenium ions in the presence of 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ). The reactivity of these cations was explored with a variety of nucleophiles. In addition, the electronic
properties were altered on the benzopyran ring system to elucidate the substrate scope for this transformation.
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Details
| Item Type: |
University of Pittsburgh ETD
|
| Status: |
Unpublished |
| Creators/Authors: |
|
| ETD Committee: |
|
| Date: |
9 October 2012 |
| Date Type: |
Publication |
| Defense Date: |
13 July 2012 |
| Approval Date: |
9 October 2012 |
| Submission Date: |
16 July 2012 |
| Access Restriction: |
No restriction; Release the ETD for access worldwide immediately. |
| Number of Pages: |
284 |
| Institution: |
University of Pittsburgh |
| Schools and Programs: |
Dietrich School of Arts and Sciences > Chemistry |
| Degree: |
PhD - Doctor of Philosophy |
| Thesis Type: |
Doctoral Dissertation |
| Refereed: |
Yes |
| Uncontrolled Keywords: |
total synthesis, oxidative chemistry, cascade reactions, Carbon–Carbon bond forming reaction, Carbon–Hydrogen functionalization |
| Date Deposited: |
09 Oct 2012 18:04 |
| Last Modified: |
15 Nov 2016 14:00 |
| URI: |
http://d-scholarship.pitt.edu/id/eprint/12914 |
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