Hong, SK and Tsang, M and Dawid, IB
(2008)
The Mych gene is required for neural crest survival during zebrafish development.
PLoS ONE, 3 (4).
Abstract
Background: Amomg Myc family genes, c-Myc is known to have a role in neural crest specification in Xenopus and in craniofacial development in the mouse. There is no information on the function of other Myc genes in neural crest development, or about any developmental role: of zebrafish Myc genes. Principal Findings: We isolated the zebrafish mych (myc homologue) gene. Knockdown of mych leads to sever defects in craniofacial development and in certain other tissues including the eye. These phenotypes appear to be caused by cell death in the neural crest and in the eye field in the anterior brain. Significance: Mych is a novel factor required for neural crest cell survival in zebrafish.
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Details
| Item Type: |
Article
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| Status: |
Published |
| Creators/Authors: |
| Creators | Email | Pitt Username | ORCID  |
|---|
| Hong, SK | | | | | Tsang, M | tsang@pitt.edu | TSANG | | | Dawid, IB | | | |
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| Contributors: |
| Contribution | Contributors Name | Email | Pitt Username | ORCID |
|---|
| Editor | Cookson, Mark R. | UNSPECIFIED | UNSPECIFIED | UNSPECIFIED |
|
| Date: |
30 April 2008 |
| Date Type: |
Publication |
| Journal or Publication Title: |
PLoS ONE |
| Volume: |
3 |
| Number: |
4 |
| DOI or Unique Handle: |
10.1371/journal.pone.0002029 |
| Refereed: |
Yes |
| PubMed ID: |
18446220 |
| Date Deposited: |
18 Jul 2012 20:39 |
| Last Modified: |
13 Oct 2017 20:55 |
| URI: |
http://d-scholarship.pitt.edu/id/eprint/12956 |
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