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The evolutionary genetics and emergence of avian influenza viruses in wild birds

Dugan, VG and Chen, R and Spiro, DJ and Sengamalay, N and Zaborsky, J and Ghedin, E and Nolting, J and Swayne, DE and Runstadler, JA and Happ, GM and Senne, DA and Wang, R and Slemons, RD and Holmes, EC and Taubenberger, JK (2008) The evolutionary genetics and emergence of avian influenza viruses in wild birds. PLoS Pathogens, 4 (5). ISSN 1553-7366

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Abstract

We surveyed the genetic diversity among avian influenza virus (AIV) in wild birds, comprising 167 complete viral genomes from 14 bird species sampled in four locations across the United States. These isolates represented 29 type A influenza virus hemagglutinin (HA) and neuraminidase (NA) subtype combinations, with up to 26% of isolates showing evidence of mixed subtype infection. Through a phylogenetic analysis of the largest data set of AIV genomes compiled to date, we were able to document a remarkably high rate of genome reassortment, with no clear pattern of gene segment association and occasional inter-hemisphere gene segment migration and reassortment. From this, we propose that AIV in wild birds forms transient "genome constellations," continually reshuffled by reassortment, in contrast to the spread of a limited number of stable genome constellations that characterizes the evolution of mammalian-adapted influenza A viruses.

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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Dugan, VG
Chen, R
Spiro, DJ
Sengamalay, N
Zaborsky, J
Ghedin, Eelg21@pitt.eduELG21
Nolting, J
Swayne, DE
Runstadler, JA
Happ, GM
Senne, DA
Wang, R
Slemons, RD
Holmes, EC
Taubenberger, JK
Contributors:
ContributionContributors NameEmailPitt UsernameORCID
EditorPerez, Daniel R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Date: 1 May 2008
Date Type: Publication
Journal or Publication Title: PLoS Pathogens
Volume: 4
Number: 5
DOI or Unique Handle: 10.1371/journal.ppat.1000076
Refereed: Yes
ISSN: 1553-7366
PubMed ID: 18516303
Date Deposited: 18 Jul 2012 20:29
Last Modified: 04 Feb 2019 16:55
URI: http://d-scholarship.pitt.edu/id/eprint/12979

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