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Working memory cells' behavior may be explained by cross-regional networks with synaptic facilitation

Verduzco-Flores, S and Bodner, M and Ermentrout, B and Fuster, JM and Zhou, Y (2009) Working memory cells' behavior may be explained by cross-regional networks with synaptic facilitation. PLoS ONE, 4 (8).

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Abstract

Neurons in the cortex exhibit a number of patterns that correlate with working memory. Specifically, averaged across trials of working memory tasks, neurons exhibit different firing rate patterns during the delay of those tasks. These patterns include: 1) persistent fixed-frequency elevated rates above baseline, 2) elevated rates that decay throughout the tasks memory period, 3) rates that accelerate throughout the delay, and 4) patterns of inhibited firing (below baseline) analogous to each of the preceding excitatory patterns. Persistent elevated rate patterns are believed to be the neural correlate of working memory retention and preparation for execution of behavioral/motor responses as required in working memory tasks. Models have proposed that such activity corresponds to stable attractors in cortical neural networks with fixed synaptic weights. However, the variability in patterned behavior and the firing statistics of real neurons across the entire range of those behaviors across and within trials of working memory tasks are typical not reproduced. Here we examine the effect of dynamic synapses and network architectures with multiple cortical areas on the states and dynamics of working memory networks. The analysis indicates that the multiple pattern types exhibited by cells in working memory networks are inherent in networks with dynamic synapses, and that the variability and firing statistics in such networks with distributed architectures agree with that observed in the cortex. © 2009 Verduzco-Flores et al.

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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Verduzco-Flores, S
Bodner, M
Ermentrout, B
Fuster, JM
Zhou, Y
Contributors:
ContributionContributors NameEmailPitt UsernameORCID
EditorSporns, Olaf Sporns,UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Date: 4 August 2009
Date Type: Publication
Journal or Publication Title: PLoS ONE
Volume: 4
Number: 8
DOI or Unique Handle: 10.1371/journal.pone.0006399
Schools and Programs: Dietrich School of Arts and Sciences > Mathematics
Refereed: Yes
MeSH Headings: Cerebral Cortex--physiology; Humans; Models, Biological; Neurons--physiology; Synapses--physiology
PubMed Central ID: PMC2715103
PubMed ID: 19652716
Date Deposited: 03 Aug 2012 15:06
Last Modified: 25 Jan 2019 21:55
URI: http://d-scholarship.pitt.edu/id/eprint/13160

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